Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Podocytes of the renal glomerulus are unique cells with a complex cellular organization
consisting of a cell body, major processes and foot processes. Podocyte foot processes form …

Hereditary Proteinuria Syndromes and Mechanisms of Proteinuria | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

The nephron is the basic structural and functional unit of the vertebrate kidney. It is
composed of a glomerulus, the site of ultrafiltration, and a renal tubule, along which the …

In the past decade, our understanding of the role of podocytes in the function of the
glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of …

Hereditary nephrotic syndrome is a heterogeneous disease, characterized by heavy
proteinuria and renal failure. Mutations of NPHS1 or NPHS2, the genes encoding for …

Podocytes are unique cells with a complex cellular organization. With respect to their
cytoarchitecture, podocytes may be divided into three structurally and functionally different …

Nephrin is a key functional component of the slit diaphragm, the structurally unresolved
molecular filter in renal glomerular capillaries. Abnormal nephrin or its absence results in …

Dysfunction of slit diaphragm, a cell–cell junction of glomerular podocytes, is involved in the
development of proteinuria in several glomerular diseases. Slit diaphragm should be a …

Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal failure.
Recent studies have emphasized the critical role of the slit diaphragm of podocytes for the …