Members of the nerve growth factor (NGF) and glial cell line-derived neurotrophic factor
(GDNF) families—comprising neurotrophins and GDNF-family ligands (GFLs), respectively …

The concept that stem cells are controlled by particular microenvironments known as' niches'
has been widely invoked. But niches have remained largely a theoretical construct because …

Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Gametogenesis is a complex biological process that is particularly sensitive to
environmental insults such as chemicals. Many chemicals have a negative impact on the …

Spermatogenesis is a complex process that originates in a small population of
spermatogonial stem cells. Here we report the in vitro culture of spermatogonial stem cells …

Spermatogonial stem cells (SSCs) self-renew and produce large numbers of committed
progenitors that are destined to differentiate into spermatozoa throughout life. However, the …

Hirschsprung disease (HSCR, aganglionic megacolon) represents the main genetic cause
of functional intestinal obstruction with an incidence of 1/5000 live births. This …

The RET receptor tyrosine kinase is crucial for normal development but also contributes to
pathologies that reflect both the loss and the gain of RET function. Activation of RET occurs …

Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial
stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with …