In the past decade, precision genomics based medicine has emerged to provide tailored
and effective healthcare for patients depending upon their genetic features. Genome Wide …

tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …

Abstract tRNA are post-transcriptionally modified by chemical modifications that affect all
aspects of tRNA biology. An increasing number of mutations underlying human genetic …

There are currently no treatments for geographic atrophy, the advanced form of age-related
macular degeneration. Hence, innovative studies are needed to model this condition and …

The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …

Type 1 diabetes mellitus (T1D) is a complex autoimmune disorder characterised by loss of
the insulin-producing pancreatic beta cells in genetically predisposed individuals, ultimately …

Little is known about how the observed fat-specific pattern of 3D-spatial genome
organisation is established. Here we report that adipocyte-specific knockout of the gene …

Abstract Background Runs of homozygosity (ROHs) are homozygous segments of the
genome where the two haplotypes inherited from the parents are identical. The current …

Posttraumatic stress disorder (PTSD) is a psychiatric disorder that may arise in response to
severe traumatic event and is diagnosed based on three main symptom clusters …

Clinical studies of non-communicable diseases identify multimorbidities that suggest a
common set of predisposing factors. Despite the fact that humans have~ 24,000 genes, we …