Toward the solution of the protein structure prediction problem
Since Anfinsen demonstrated that the information encoded in a protein's amino acid
sequence determines its structure in 1973, solving the protein structure prediction problem …
sequence determines its structure in 1973, solving the protein structure prediction problem …
Progress and challenges in protein structure prediction
Y Zhang - Current opinion in structural biology, 2008 - Elsevier
Depending on whether similar structures are found in the PDB library, the protein structure
prediction can be categorized into template-based modeling and free modeling. Although …
prediction can be categorized into template-based modeling and free modeling. Although …
AlphaFold 2: why it works and its implications for understanding the relationships of protein sequence, structure, and function
AlphaFold 2 (AF2) was the star of CASP14, the last biannual structure prediction experiment.
Using novel deep learning, AF2 predicted the structures of many difficult protein targets at or …
Using novel deep learning, AF2 predicted the structures of many difficult protein targets at or …
TM-align: a protein structure alignment algorithm based on the TM-score
We have developed TM-align, a new algorithm to identify the best structural alignment
between protein pairs that combines the TM-score rotation matrix and Dynamic …
between protein pairs that combines the TM-score rotation matrix and Dynamic …
Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is a
newly recognized condition in children with recent severe acute respiratory syndrome …
newly recognized condition in children with recent severe acute respiratory syndrome …
Benchmarking refined and unrefined AlphaFold2 structures for hit discovery
The recently developed AlphaFold2 (AF2) algorithm predicts proteins' 3D structures from
amino acid sequences. The open AlphaFold protein structure database covers the complete …
amino acid sequences. The open AlphaFold protein structure database covers the complete …
Deep‐learning contact‐map guided protein structure prediction in CASP13
We report the results of two fully automated structure prediction pipelines,“Zhang‐Server”
and “QUARK”, in CASP13. The pipelines were built upon the C‐I‐TASSER and C‐QUARK …
and “QUARK”, in CASP13. The pipelines were built upon the C‐I‐TASSER and C‐QUARK …
Protein structure and folding pathway prediction based on remote homologs recognition using PAthreader
Recognition of remote homologous structures is a necessary module in AlphaFold2 and is
also essential for the exploration of protein folding pathways. Here, we propose a method …
also essential for the exploration of protein folding pathways. Here, we propose a method …
Ab initio modeling of small proteins by iterative TASSER simulations
Background Predicting 3-dimensional protein structures from amino-acid sequences is an
important unsolved problem in computational structural biology. The problem becomes …
important unsolved problem in computational structural biology. The problem becomes …
I‐TASSER: Fully automated protein structure prediction in CASP8
Y Zhang - Proteins: Structure, Function, and Bioinformatics, 2009 - Wiley Online Library
The I‐TASSER algorithm for 3D protein structure prediction was tested in CASP8, with the
procedure fully automated in both the Server and Human sections. The quality of the server …
procedure fully automated in both the Server and Human sections. The quality of the server …