Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With
its unique sulfonic acid makeup, taurine influences cellular functions, including …

Inflammation contributes to the tubulointerstitial lesions of diabetic nephropathy. Toll-like
receptors (TLRs) modulate immune responses and inflammatory diseases, but their role in …

The innate immune system is the first line of defense in response to nonself and danger
signals from microbial invasion or tissue injury. It is increasingly recognized that each organ …

While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to kidney
injury induced by ischemia and reperfusion, the relevance of TLR4 activation to allograft …

Graft inflammation impairs the induction of solid organ transplant tolerance and enhances
acute and chronic rejection. Elucidating the mechanisms by which inflammation is induced …

Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs)
are families of pattern recognition receptors that, together with inflammasomes, sense and …

Abstract Toll-like receptor 4 (TLR4) is an important pathogen recognition receptor that
recognizes mainly lipopolysaccharide (LPS) of Gram-negative bacteria, but also structures …

Despite remarkable advances in the diagnostic and therapeutic modalities for its
management, cytomegalovirus (CMV) remains one of the most important pathogens …

Toll-like receptors (TLRs) have a key role in innate immunity. These receptors recognize
both pathogen-associated molecular patterns and molecules that are released from …