Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and …

The genotype–fitness map (that is, the fitness landscape) is a key determinant of evolution,
yet it has mostly been used as a superficial metaphor because we know little about its …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Addressing the emergence of life from a systems biology perspective, this new edition has
undergone extensive revision, reflecting changes in scientific understanding and evolution …

Several types of pediatric cancers reportedly contain high-frequency missense mutations in
histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here …

The structure of fitness landscapes is critical for understanding adaptive protein evolution.
Previous empirical studies on fitness landscapes were confined to either the neighborhood …

Evolve and resequence (E&R) experiments use experimental evolution to adapt populations
to a novel environment, then next-generation sequencing to analyse genetic changes. They …

Understanding how life on Earth might have originated is the major goal of origins of life
chemistry. To proceed from simple feedstock molecules and energy sources to a living …

By formalizing the relationship between genotype or phenotype and fitness, fitness
landscapes harbor information on molecular and evolutionary constraints. The shape of the …

High-throughput sequence (HTS) analysis of combinatorial selection populations
accelerates lead discovery and optimization and offers dynamic insight into selection …