The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …

Cancer, infectious diseases, and metabolic and hereditary genetic disorders are a global
health burden affecting millions of people, with contemporary treatments offering limited …

Distribution shifts—where the training distribution differs from the test distribution—can
substantially degrade the accuracy of machine learning (ML) systems deployed in the wild …

Low oxygen tension (hypoxia) is a pervasive physiological and pathophysiological stimulus
that metazoan organisms have contended with since they evolved from their single-celled …

Recent technological advances have enabled DNA methylation to be assayed at single-cell
resolution. However, current protocols are limited by incomplete CpG coverage and hence …

Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism,
and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can …

Abstract We developed Lisa (http://lisa. cistrome. org/) to predict the transcriptional
regulators (TRs) of differentially expressed or co-expressed gene sets. Based on the input …

We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

Paragangliomas and pheochromocytomas (PPGL) are rare neuroendocrine tumours
characterized by a strong genetic determinism. Over the past 20 years, evolution of PPGL …

INTRODUCTION The adaptive immune system has evolved to mount different types of
responses that are matched to the type of invading pathogen. For CD4+ T cells, this is …