FreeSurfer‐based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other …

PG Sämann, JE Iglesias, B Gutman… - Human brain …, 2022‏ - Wiley Online Library
Structural hippocampal abnormalities are common in many neurological and psychiatric
disorders, and variation in hippocampal measures is related to cognitive performance and …

Stress during critical periods of development and risk for schizophrenia

FV Gomes, X Zhu, AA Grace - Schizophrenia research, 2019‏ - Elsevier
Schizophrenia is a neurodevelopmental disorder with genetic predisposition, and stress has
long been linked to its etiology. While stress affects all stages of the illness, increasing …

Hippocampal circuit dysfunction in psychosis

S Knight, R McCutcheon, D Dwir, AA Grace… - Translational …, 2022‏ - nature.com
Despite strong evidence of the neurodevelopmental origins of psychosis, current
pharmacological treatment is not usually initiated until after a clinical diagnosis is made, and …

Exercise intervention in individuals at clinical high risk for psychosis: benefits to fitness, symptoms, hippocampal volumes, and functional connectivity

KSF Damme, T Gupta, I Ristanovic, D Kimhy… - Schizophrenia …, 2022‏ - academic.oup.com
Abstract Background and Hypothesis Individuals at clinical high risk for psychosis (CHR-p)
are less fit than nonclinical peers and show hippocampal abnormalities that relate to clinical …

Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors

A Schmitt, P Falkai, S Papiol - Journal of neural transmission, 2023‏ - Springer
Since more than 3 decades, schizophrenia (SZ) has been regarded as a
neurodevelopmental disorder. The neurodevelopmental hypothesis proposes that SZ is …

Hippocampal glutamate and hippocampus subfield volumes in antipsychotic-naive first episode psychosis subjects and relationships to duration of untreated …

F Briend, EA Nelson, O Maximo, WP Armstrong… - Translational …, 2020‏ - nature.com
Evidence points toward a relationship between longer duration of untreated psychosis
(DUP) and worse long-term outcomes in patients with first episode psychosis (FEP), but the …

Disturbed oligodendroglial maturation causes cognitive dysfunction in schizophrenia: a new hypothesis

P Falkai, MJ Rossner, FJ Raabe, E Wagner… - Schizophrenia …, 2023‏ - academic.oup.com
Abstract Background and Hypothesis Cognitive impairment is a hallmark of schizophrenia,
but no effective treatment is available to date. The underlying pathophysiology includes …

Hippocampal volume in early psychosis: a 2-year longitudinal study

M McHugo, K Armstrong, MJ Roeske… - Translational …, 2020‏ - nature.com
Cross-sectional studies suggest that hippocampal volume declines across stages of
psychosis. In contrast, longitudinal studies indicate that hippocampal volume is stable in the …

[HTML][HTML] Decreased oligodendrocyte number in hippocampal subfield CA4 in schizophrenia: a replication study

A Schmitt, L Tatsch, A Vollhardt, T Schneider-Axmann… - Cells, 2022‏ - mdpi.com
Hippocampus-related cognitive deficits in working and verbal memory are frequent in
schizophrenia, and hippocampal volume loss, particularly in the cornu ammonis (CA) …

Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS

V Mancini, C Sandini, MC Padula, D Zöller… - Molecular …, 2020‏ - nature.com
Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis
spectrum. However, there is a lack of studies investigating longitudinal hippocampal …