NAMPT and NAPRT: two metabolic enzymes with key roles in inflammation

V Audrito, VG Messana, S Deaglio - Frontiers in oncology, 2020 - frontiersin.org
Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate
phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step …

Metabolic regulation of histone post-translational modifications

J Fan, KA Krautkramer, JL Feldman… - ACS chemical …, 2015 - ACS Publications
Histone post-translational modifications regulate transcription and other DNA-templated
functions. This process is dynamically regulated by specific modifying enzymes whose …

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

A Rio-Machin, T Vulliamy, N Hug, A Walne… - Nature …, 2020 - nature.com
The inclusion of familial myeloid malignancies as a separate disease entity in the revised
WHO classification has renewed efforts to improve the recognition and management of this …

Analysis of cancer-related lncRNAs using gene ontology and KEGG pathways

L Chen, YH Zhang, G Lu, T Huang, YD Cai - Artificial intelligence in …, 2017 - Elsevier
Background Cancer is a disease that involves abnormal cell growth and can invade or
metastasize to other tissues. It is known that several factors are related to its initiation …

Beyond energy metabolism: exploiting the additional roles of NAMPT for cancer therapy

CM Heske - Frontiers in oncology, 2020 - frontiersin.org
Tumor cells have increased requirements for NAD+. Thus, many cancers exhibit an
increased reliance on NAD+ production pathways. This dependence may be exploited …

The role of adipokines in breast cancer: current evidence and perspectives

GS Christodoulatos, N Spyrou, J Kadillari… - Current obesity …, 2019 - Springer
Purpose The current review shows evidence for the role of adipokines in breast cancer (BC)
pathogenesis summarizing the mechanisms underlying the association between adipokines …

Classic and novel adipocytokines at the intersection of obesity and cancer: diagnostic and therapeutic strategies

N Spyrou, KI Avgerinos, CS Mantzoros… - Current obesity …, 2018 - Springer
Abstract Purpose of Review In this review, we investigate the role of classic and novel
adipocytokines in cancer pathogenesis synopsizing the mechanisms underlying the …

The role of extracellular and intracellular Nicotinamide phosphoribosyl-transferase in cancer: Diagnostic and therapeutic perspectives and challenges

M Dalamaga, GS Christodoulatos, CS Mantzoros - Metabolism, 2018 - Elsevier
Nicotinamide phosphoribosyl-transferase (Nampt) or pre-B cell colony-enhancing factor or
visfatin represents a pleiotropic molecule acting as an enzyme, a cytokine and a growth …

[HTML][HTML] Impact of ERG3 mutations and expression of ergosterol genes controlled by UPC2 and NDT80 in Candida parapsilosis azole resistance

J Branco, M Ola, RM Silva, E Fonseca… - Clinical Microbiology …, 2017 - Elsevier
Objectives Candida parapsilosis is a healthcare-related fungal pathogen particularly
common among immunocompromised patients. Our understanding of antifungal resistance …

Altered epigenetic profiles in the placenta of preeclamptic and intrauterine growth restriction patients

C Norton, D Clarke, J Holmstrom, I Stirland… - Cells, 2023 - mdpi.com
Intrauterine growth restriction (IUGR) and preeclampsia (PE) are placental pathologies
known to complicate pregnancy and cause neonatal disorders. To date, there is a limited …