Recent progress shows that neurons suitable for transplantation can be generated from
stem cells in culture, and that the adult brain produces new neurons from its own stem cells …

A variety of neurological disorders are attractive targets for stem and progenitor cell-based
therapy. Yet many conditions are not, whether by virtue of an inhospitable disease …

To direct human embryonic stem (HES) cells to a dopaminergic neuronal fate, we cocultured
HES cells that were exposed to both sonic hedgehog and fibroblast growth factor 8 with …

Secondary injury exacerbates the extent of spinal cord insults, yet the mechanistic basis of
this phenomenon has largely been unexplored. Here we report that broad regions of the …

Background BM-derived mesenchymal stem cells (MSC) are attractive sources for
autotransplantation with no risk of rejection, but the use of these cells has problems …

Cancer may arise from a cancer stem/progenitor cell that shares characteristics with its
normal counterpart. We report the reconstitution of the original human prostate cancer …

Telomere length and cell function can be preserved by the human reverse transcriptase
telomerase (hTERT), which synthesizes the new telomeric DNA from a RNA template, but is …

Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy …

Multipotent neural stem cells, capable of giving rise to both neurons and glia, line the
cerebral ventricles of all adult animals, including humans. In addition, distinct populations of …

No effective therapy is currently available to promote recovery following ischemic stroke.
Stem cells have been proposed as a potential source of new cells to replace those lost due …