Advances in computerized MRI‐based biomarkers in Alzheimer's disease

R Wong, Y Luo, VC Mok, L Shi - Brain Science Advances, 2021 - journals.sagepub.com
The use of neuroimaging examinations is crucial in Alzheimer's disease (AD), in both
research and clinical settings. Over the years, magnetic resonance imaging (MRI)–based …

Structure focused neurodegeneration convolutional neural network for modelling and classification of Alzheimer's disease

S Odimayo, CC Olisah, K Mohammed - Scientific Reports, 2024 - nature.com
Abstract Alzheimer's disease (AD), the predominant form of dementia, is a growing global
challenge, emphasizing the urgent need for accurate and early diagnosis. Current clinical …

An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer's disease

Q Yu, Y Mai, Y Ruan, Y Luo, L Zhao, W Fang… - Alzheimer's research & …, 2021 - Springer
Background The differential diagnosis of frontotemporal dementia (FTD) and Alzheimer's
disease (AD) is difficult due to the overlaps of clinical symptoms. Structural magnetic …

Comparing machine learning‐derived MRI‐based and blood‐based neurodegeneration biomarkers in predicting syndromal conversion in early AD

Y Cai, X Fan, L Zhao, W Liu, Y Luo… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction We compared the machine learning‐derived, MRI‐based Alzheimer's disease
(AD) resemblance atrophy index (AD‐RAI) with plasma neurofilament light chain (NfL) level …

Automated brain volumetric measures with AccuBrain: version comparison in accuracy, reproducibility and application for diagnosis

L Zhao, Y Luo, V Mok, L Shi - BMC Medical Imaging, 2022 - Springer
Background Automated brain volumetry has been widely used to assess brain volumetric
changes that may indicate clinical states and progression. Among the tools that implement …

The correlation between white matter hyperintensity burden and regional brain volumetry in patients with Alzheimer's disease

Z Cao, Y Mai, W Fang, M Lei, Y Luo, L Zhao… - Frontiers in Human …, 2022 - frontiersin.org
Background White matter hyperintensities (WMHs) and regional brain lobe atrophy coexist
in the brain of patients with Alzheimer's disease (AD), but the association between them in …

Association between periodic limb movements during sleep and neuroimaging features of cerebral small vessel disease: A preliminary cross‐sectional study

F Ouyang, M Wang, M Liao, L Lan, X Liu… - Journal of Sleep …, 2022 - Wiley Online Library
Evidence on the relationship between periodic limb movements during sleep (PLMS) and
cerebral small vessel disease is lacking. This study aimed to assess the association …

Advancing Tau PET quantification in Alzheimer disease with machine learning: introducing THETA, a novel tau summary measure

RK Gebre, AM Rial, S Raghavan… - Journal of Nuclear …, 2024 - jnm.snmjournals.org
Alzheimer disease (AD) exhibits spatially heterogeneous 3-or 4-repeat tau deposition
across participants. Our overall goal was to develop an automated method to quantify the …

AD resemblance atrophy index as a diagnostic biomarker for Alzheimer's disease: a retrospective clinical and biological validation

Y Mai, Q Yu, F Zhu, Y Luo, W Liao… - Journal of …, 2021 - journals.sagepub.com
Background: Magnetic resonance imaging (MRI) provides objective information about brain
structural atrophy in patients with Alzheimer's disease (AD). This multi-structural atrophic …

MRI-based Alzheimer's disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer's disease

W Liu, LWC Au, J Abrigo, Y Luo, A Wong… - Aging (Albany …, 2021 - pmc.ncbi.nlm.nih.gov
Alzheimer's Disease-resemblance atrophy index (AD-RAI) is an MRI-based machine
learning derived biomarker that was developed to reflect the characteristic brain atrophy …