Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
T‐cell exhaustion in HIV infection
C Fenwick, V Joo, P Jacquier, A Noto… - Immunological …, 2019 - Wiley Online Library
The T‐cell response is central in the adaptive immune‐mediated elimination of pathogen‐
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
[HTML][HTML] Phenotypic signatures of immune selection in HIV-1 reservoir cells
Abstract Human immunodeficiency virus 1 (HIV-1) reservoir cells persist lifelong despite
antiretroviral treatment, but may be vulnerable to host immune responses that could be …
antiretroviral treatment, but may be vulnerable to host immune responses that could be …
Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
Human T cells coordinate adaptive immunity in diverse anatomic compartments through
production of cytokines and effector molecules, but it is unclear how tissue site influences T …
production of cytokines and effector molecules, but it is unclear how tissue site influences T …
Immune checkpoint blockade in infectious diseases
The upregulation of immune checkpoint molecules, such as programmed cell death protein
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
[HTML][HTML] Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones
Understanding the drivers and markers of clonally expanding HIV-1-infected CD4+ T cells is
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …
The role of PD-1 in acute and chronic infection
JM Jubel, ZR Barbati, C Burger, DC Wirtz… - Frontiers in …, 2020 - frontiersin.org
PD-1 as an immune checkpoint molecule down-regulates T cell activity during immune
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders
X Yang, B Su, X Zhang, Y Liu, H Wu… - Journal of leukocyte …, 2020 - academic.oup.com
The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …