Ageing, cellular senescence and neurodegenerative disease
Ageing is a major risk factor for develo** many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …
senescence is a homeostatic biological process that has a key role in driving ageing. There …
Cellular senescence in neurodegenerative diseases
C Martínez-Cué, N Rueda - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …
of cell cycle arrest that can contribute to the decline of the regenerative potential and …
Glucocerebrosidase and its relevance to Parkinson disease
J Do, C McKinney, P Sharma, E Sidransky - Molecular neurodegeneration, 2019 - Springer
Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are
among the most common known genetic risk factors for the development of Parkinson …
among the most common known genetic risk factors for the development of Parkinson …
Reactive oxygen species as a link between antioxidant pathways and autophagy
D Li, Z Ding, K Du, X Ye… - Oxidative Medicine and …, 2021 - Wiley Online Library
Reactive oxygen species (ROS) are highly reactive molecules that can oxidize proteins,
lipids, and DNA. Under physiological conditions, ROS are mainly generated in the …
lipids, and DNA. Under physiological conditions, ROS are mainly generated in the …
Neuronal soma-derived degradative lysosomes are continuously delivered to distal axons to maintain local degradation capacity
Neurons face the challenge of maintaining cellular homeostasis through lysosomal
degradation. While enzymatically active degradative lysosomes are enriched in the soma …
degradation. While enzymatically active degradative lysosomes are enriched in the soma …
Lipids at the crossroad of α-synuclein function and dysfunction: biological and pathological implications
NP Alza, PA Iglesias González, MA Conde… - Frontiers in Cellular …, 2019 - frontiersin.org
Since its discovery, the study of the biological role of α-synuclein and its pathological
implications has been the subject of increasing interest. The propensity to adopt different …
implications has been the subject of increasing interest. The propensity to adopt different …
Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo
GBA1 mutations that encode lysosomal β-glucocerebrosidase (GCase) cause the lysosomal
storage disorder Gaucher disease (GD) and are strong risk factors for synucleinopathies …
storage disorder Gaucher disease (GD) and are strong risk factors for synucleinopathies …
TFEB biology and agonists at a glance
M Chen, Y Dai, S Liu, Y Fan, Z Ding, D Li - Cells, 2021 - mdpi.com
Autophagy is a critical regulator of cellular survival, differentiation, development, and
homeostasis, dysregulation of which is associated with diverse diseases including cancer …
homeostasis, dysregulation of which is associated with diverse diseases including cancer …
Clinical, mechanistic, biomarker, and therapeutic advances in GBA1-associated Parkinson's disease
X Zhang, H Wu, B Tang, J Guo - Translational Neurodegeneration, 2024 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease. The
development of PD is closely linked to genetic and environmental factors, with GBA1 …
development of PD is closely linked to genetic and environmental factors, with GBA1 …
GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice
I Gregorio, L Russo, E Torretta, P Barbacini… - Molecular …, 2024 - Springer
Background Mutations in the β-glucocerebrosidase (GBA1) gene do cause the lysosomal
storage Gaucher disease (GD) and are among the most frequent genetic risk factors for …
storage Gaucher disease (GD) and are among the most frequent genetic risk factors for …