Chronic inflammation in many infectious and metabolic diseases, and some cancers, is
accompanied by the presence of foam cells. These cells form when the intracellular lipid …

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …

While the existence of a special relationship between Mycobacterium tuberculosis (Mtb) and
host lipids has long been known, it remains a challenging enigma. It was clearly established …

Heightened morbidity and mortality in pulmonary tuberculosis (TB) are consequences of
complex disease processes triggered by the causative agent, Mycobacterium tuberculosis …

Macrophages, the major host cells harboring Mycobacterium tuberculosis (M. tb), are a
heterogeneous cell type depending on their tissue of origin and host they are derived from …

In the face of ineffective vaccines, increasing antibiotic resistance and the decline in new
antibacterial drugs in the pipeline, tuberculosis (TB) still remains pandemic. Exposure to …

Macrophage derived foam cells in atherosclerotic plaques are the major factor responsible
for the pathogenesis of atherosclerosis (AS). During advanced AS, macrophage-specific …

Host-directed therapies are a relatively new and promising approach to treatment of
tuberculosis. Modulation of specific host immune pathways, including those that impact …

Lipid species play a critical role in the growth and virulence expression of Mycobacterium
tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy …

In view of emerging drug-resistant tuberculosis (TB), host-directed adjunct therapies are
urgently needed to improve treatment outcomes with currently available anti-TB therapies …