Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options

T Karampatakis, K Tsergouli, P Behzadi - Antibiotics, 2023 - mdpi.com
Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Klebsiella species: Taxonomy, hypervirulence and multidrug resistance

N Dong, X Yang, EWC Chan, R Zhang, S Chen - EBioMedicine, 2022 - thelancet.com
Members of the genus Klebsiella have rapidly evolved within the past decade, generating
organisms that simultaneously exhibit both multidrug resistance and hypervirulence (MDR …

A genomic surveillance framework and genoty** tool for Klebsiella pneumoniae and its related species complex

MMC Lam, RR Wick, SC Watts, LT Cerdeira… - Nature …, 2021 - nature.com
Klebsiella pneumoniae is a leading cause of antimicrobial-resistant (AMR) healthcare-
associated infections, neonatal sepsis and community-acquired liver abscess, and is …

Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives

JE Choby, J Howard‐Anderson… - Journal of internal …, 2020 - Wiley Online Library
Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a concerning global
pathogen. hvKp is more virulent than classical K. pneumoniae (cKp) and capable of causing …

[HTML][HTML] A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae

P Lan, Y Jiang, J Zhou, Y Yu - Journal of global antimicrobial resistance, 2021 - Elsevier
Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary
directions for Klebsiella pneumoniae, which pose a great threat in clinical settings. Multiple …

Klebsiella pneumoniae infection biology: living to counteract host defences

JA Bengoechea, J Sa Pessoa - FEMS microbiology reviews, 2019 - academic.oup.com
Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

[HTML][HTML] Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

KL Wyres, KE Holt - Current opinion in microbiology, 2018 - Elsevier
Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency
and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant …

Carbapenem resistance-encoding and virulence-encoding conjugative plasmids in Klebsiella pneumoniae

X Yang, N Dong, EWC Chan, R Zhang, S Chen - Trends in microbiology, 2021 - cell.com
Klebsiella pneumoniae has an exceptional ability to acquire exogenous resistance-
encoding and hypervirulence-encoding genetic elements. In this review we trace the key …

Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae

CM Ernst, JR Braxton, CA Rodriguez-Osorio… - Nature medicine, 2020 - nature.com
Among the most urgent public health threats is the worldwide emergence of carbapenem-
resistant Enterobacteriaceae,,–, which are resistant to the antibiotic class of 'last resort'. In …