Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview

F Garcia-Ochoa, E Gomez - Biotechnology advances, 2009 - Elsevier
In aerobic bioprocesses, oxygen is a key substrate; due to its low solubility in broths
(aqueous solutions), a continuous supply is needed. The oxygen transfer rate (OTR) must be …

Oxygen uptake rate in microbial processes: an overview

F Garcia-Ochoa, E Gomez, VE Santos… - Biochemical engineering …, 2010 - Elsevier
In aerobic process oxygen must be continuously supplied in order to achieve acceptable
productivities, Since the role of oxygen in microorganism growth and its metabolism is of …

Large‐scale biodiesel production from microalga Chlorella protothecoides through heterotrophic cultivation in bioreactors

X Li, H Xu, Q Wu - Biotechnology and bioengineering, 2007 - Wiley Online Library
An integrated approach of biodiesel production from heterotrophic Chlorella protothecoides
focused on scaling up fermentation in bioreactors was reported in this study. Through …

H2 gas-liquid mass transfer: A key element in biological Power-to-Gas methanation

MB Jensen, LDM Ottosen, MVW Kofoed - Renewable and Sustainable …, 2021 - Elsevier
Power-to-Gas technologies are considered essential for a green transition of the global
energy system by producing fossil-free fuel from renewable electricity and CO 2. Biological …

Essential prerequisites for successful bioprocess development of biological CH4 production from CO2 and H2

S Rittmann, A Seifert, C Herwig - Critical reviews in biotechnology, 2015 - Taylor & Francis
The production and storage of energy from renewable resources steadily increases in
importance. One opportunity is to utilize carbon dioxide (CO2)-type hydrogenotrophic …

Evaluation of mixing and mass transfer in a stirred pilot scale bioreactor utilizing CFD

C Bach, J Yang, H Larsson, SM Stocks… - Chemical engineering …, 2017 - Elsevier
Abstract Knowledge and prediction of mixing and mass transfer in agitated bioreactors is
fundamental for process development and scale up. In particular key process parameters …

Development of a scale-up strategy for an aerated coaxial mixer containing a non-Newtonian fluid: A mass transfer approach

A Rahimzadeh, F Ein-Mozaffari, A Lohi - Physics of Fluids, 2023 - pubs.aip.org
Coaxial mixers have been shown to be effective in enhancing the hydrodynamic stress and
shear environment inside the aerated systems. However, the scale-up study of the aerated …

New insights into the gas dispersion and mass transfer in shear-thinning fluids inside an aerated coaxial mixer via analysis of flow hydrodynamics and shear …

A Rahimzadeh, F Ein-Mozaffari… - Industrial & Engineering …, 2022 - ACS Publications
The performance of an agitated bioreactor is hampered by an intense shear environment
and low mass-transfer coefficient (k L a). The gas hold-up, k L a, and shear environment …

Influence of process parameters on growth of Clostridium ljungdahlii and Clostridium autoethanogenum on synthesis gas

JL Cotter, MS Chinn, AM Grunden - Enzyme and Microbial Technology, 2009 - Elsevier
Effects of initial medium pH and gas flow rate on Clostridium ljungdahlii and Clostridium
autoethanogenum in liquid batch, continuous gas fermentations were investigated …

Bioprocess scale‐up: quest for the parameters to be used as criterion to move from microreactors to lab‐scale

MPC Marques, JMS Cabral… - Journal of Chemical …, 2010 - Wiley Online Library
Advances in high‐throughput process development and optimization involve the rational
use of miniaturized stirred bioreactors, instrumented shaken flasks and microtiter plates. As …