The role of mitochondria in myocardial damage caused by energy metabolism disorders: From mechanisms to therapeutics

A Li, L Lian, X Chen, W Cai, X Fan, Y Fan, T Li… - Free Radical Biology …, 2023 - Elsevier
Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023

TP Burris, IMS de Vera, I Cote, CA Flaveny… - Pharmacological …, 2023 - Elsevier
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

A synthetic ERR agonist alleviates metabolic syndrome

C Billon, E Schoepke, A Avdagic, A Chatterjee… - The Journal of …, 2024 - Elsevier
Physical exercise induces physiologic adaptations and is effective at reducing the risk of
premature death from all causes. Pharmacological exercise mimetics may be effective in the …

METTL3 promotes proliferation and myogenic differentiation through m6A RNA methylation/YTHDF1/2 signaling axis in myoblasts

T Zhao, R Zhao, X Yi, R Cai, W Pang - Life Sciences, 2022 - Elsevier
Skeletal muscle development has an important impact on muscle-related diseases and
domestic animal meat production. The m 6 A RNA methylation is a common post …

Exploring the impact of estrogen-related receptor gamma on metabolism and disease

N Sadasivam, WR Park, B Choi, YS Jung, HS Choi… - Steroids, 2024 - Elsevier
Estrogen-related receptor gamma (ERRγ) is a member of the ERR orphan nuclear receptor
family which possesses three subtypes, α, β, and γ. ERRγ is reportedly predominantly …

Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915

CS Hampton, S Sitaula, C Billon, K Haynes… - European journal of …, 2023 - Elsevier
Estrogen-related receptors (ERR) are an orphan nuclear receptor sub-family that play a
critical role in regulating gene transcription for several physiological processes including …

[HTML][HTML] Pharmacophore modeling for biological targets with high flexibility: LXRβ case study

S Kchouk, L Hegazy - Medicine in Drug Discovery, 2022 - Elsevier
Many biological targets are characterized by high binding pocket flexibility posing a
challenge in identifying important ligand binding features. Liver X receptors (LXRs) are …

Oxovanadium(V) catalysts for the CO2 fixation into cyclic carbonates under ambient pressure

TY Chen, CH Liu, ML Tsai - Journal of the Chinese Chemical …, 2022 - Wiley Online Library
Develo** feasible strategies to utilize CO2 as a C1 synthon for constructing various
valued‐added chemical feedstock is crucial for alleviating the global warning and achieving …

Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRα-targeted anti-mitotic agents

Q Wang, X Tu, X Wang, Q Cai, L Yu, X Zhang, J Yi… - Bioorganic …, 2022 - Elsevier
RXRα, a unique and important nuclear receptor, plays a vital role in various biological and
pathological pathways, including growth, differentiation, and apoptosis. We recently reported …

Synthesis and structure activity relationship of the first class of LXR inverse agonists

B Elgendy, K Griffett, L Hegazy, P Di Fruscia… - Bioorganic …, 2022 - Elsevier
Abstract Liver X Receptors (LXRs) are members of the nuclear receptor family, and they play
significant role in lipid and cholesterol metabolism. Moreover, they are key regulators of …