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The role of mitochondria in myocardial damage caused by energy metabolism disorders: From mechanisms to therapeutics
A Li, L Lian, X Chen, W Cai, X Fan, Y Fan, T Li… - Free Radical Biology …, 2023 - Elsevier
Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …
diseases and an important reason for their high mortality. In recent years, because of the …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
A synthetic ERR agonist alleviates metabolic syndrome
Physical exercise induces physiologic adaptations and is effective at reducing the risk of
premature death from all causes. Pharmacological exercise mimetics may be effective in the …
premature death from all causes. Pharmacological exercise mimetics may be effective in the …
METTL3 promotes proliferation and myogenic differentiation through m6A RNA methylation/YTHDF1/2 signaling axis in myoblasts
T Zhao, R Zhao, X Yi, R Cai, W Pang - Life Sciences, 2022 - Elsevier
Skeletal muscle development has an important impact on muscle-related diseases and
domestic animal meat production. The m 6 A RNA methylation is a common post …
domestic animal meat production. The m 6 A RNA methylation is a common post …
Exploring the impact of estrogen-related receptor gamma on metabolism and disease
N Sadasivam, WR Park, B Choi, YS Jung, HS Choi… - Steroids, 2024 - Elsevier
Estrogen-related receptor gamma (ERRγ) is a member of the ERR orphan nuclear receptor
family which possesses three subtypes, α, β, and γ. ERRγ is reportedly predominantly …
family which possesses three subtypes, α, β, and γ. ERRγ is reportedly predominantly …
Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915
CS Hampton, S Sitaula, C Billon, K Haynes… - European journal of …, 2023 - Elsevier
Estrogen-related receptors (ERR) are an orphan nuclear receptor sub-family that play a
critical role in regulating gene transcription for several physiological processes including …
critical role in regulating gene transcription for several physiological processes including …
[HTML][HTML] Pharmacophore modeling for biological targets with high flexibility: LXRβ case study
S Kchouk, L Hegazy - Medicine in Drug Discovery, 2022 - Elsevier
Many biological targets are characterized by high binding pocket flexibility posing a
challenge in identifying important ligand binding features. Liver X receptors (LXRs) are …
challenge in identifying important ligand binding features. Liver X receptors (LXRs) are …
Oxovanadium(V) catalysts for the CO2 fixation into cyclic carbonates under ambient pressure
TY Chen, CH Liu, ML Tsai - Journal of the Chinese Chemical …, 2022 - Wiley Online Library
Develo** feasible strategies to utilize CO2 as a C1 synthon for constructing various
valued‐added chemical feedstock is crucial for alleviating the global warning and achieving …
valued‐added chemical feedstock is crucial for alleviating the global warning and achieving …
Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRα-targeted anti-mitotic agents
Q Wang, X Tu, X Wang, Q Cai, L Yu, X Zhang, J Yi… - Bioorganic …, 2022 - Elsevier
RXRα, a unique and important nuclear receptor, plays a vital role in various biological and
pathological pathways, including growth, differentiation, and apoptosis. We recently reported …
pathological pathways, including growth, differentiation, and apoptosis. We recently reported …
Synthesis and structure activity relationship of the first class of LXR inverse agonists
Abstract Liver X Receptors (LXRs) are members of the nuclear receptor family, and they play
significant role in lipid and cholesterol metabolism. Moreover, they are key regulators of …
significant role in lipid and cholesterol metabolism. Moreover, they are key regulators of …