Activity‐based NIR enzyme fluorescent probes for the diagnosis of tumors and image‐guided surgery

H Li, D Kim, Q Yao, H Ge, J Chung, J Fan… - Angewandte …, 2021 - Wiley Online Library
Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective
edge tools for the investigation of cell biology and disease diagnosis because of their …

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

HW Liu, L Chen, C Xu, Z Li, H Zhang… - Chemical Society …, 2018 - pubs.rsc.org
Abnormal enzymatic activities are directly related to the development of cancers. Identifying
the location and expression levels of these enzymes in live cancer cells have considerable …

Fluorogenic probes for disease-relevant enzymes

J Zhang, X Chai, XP He, HJ Kim, J Yoon… - Chemical Society …, 2019 - pubs.rsc.org
Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

Fluorescent probes for sensing and imaging within specific cellular organelles

H Zhu, J Fan, J Du, X Peng - Accounts of chemical research, 2016 - ACS Publications
Conspectus Fluorescent probes have become powerful tools in biosensing and bioimaging
because of their high sensitivity, specificity, fast response, and technical simplicity. In the last …

Cancer biomarker detection: recent achievements and challenges

L Wu, X Qu - Chemical Society Reviews, 2015 - pubs.rsc.org
The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …

1, 8-Naphthalimide based fluorescent sensors for enzymes

C Geraghty, C Wynne, RBP Elmes - Coordination Chemistry Reviews, 2021 - Elsevier
Fluorescent probes have long been valuable tools in the study of biological systems. With
the ever-expanding range of known enzymatic biomarkers for disease, it has never been …

NAD (P) H: quinone oxidoreductase 1 (NQO1) as a therapeutic and diagnostic target in cancer

K Zhang, D Chen, K Ma, X Wu, H Hao… - Journal of Medicinal …, 2018 - ACS Publications
NAD (P) H: quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for
detoxification of quinones and also bioactivation of certain quinones. It is abnormally …

Cytosolic NQO1 enzyme-activated near-infrared fluorescence imaging and photodynamic therapy with polymeric vesicles

C Yao, Y Li, Z Wang, C Song, X Hu, S Liu - ACS nano, 2020 - ACS Publications
The utilization of enzymes as a triggering module could endow responsive polymeric
nanostructures with selectivity in a site-specific manner. On the basis of the fact that …

Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging

W Chyan, RT Raines - ACS chemical biology, 2018 - ACS Publications
Fluorogenic probes, small-molecule sensors that unmask brilliant fluorescence upon
exposure to specific stimuli, are powerful tools for chemical biology. Those probes that …

A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging

R Wang, J Chen, J Gao, JA Chen, G Xu, T Zhu… - Chemical …, 2019 - pubs.rsc.org
The advance of cancer imaging requires innovations to establish novel fluorescent scaffolds
that are excitable and emit in the near-infrared region with favorable Stokes shifts …