Tumour-associated macrophages as treatment targets in oncology
Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …
Cancer inflammation and cytokines
MR Galdiero, G Marone… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Chronic inflammation is a well-recognized tumor-enabling capability, which allows nascent
tumors to escape immunosurveillance. A number of soluble and cellular inflammatory …
tumors to escape immunosurveillance. A number of soluble and cellular inflammatory …
Engineering endogenous tumor‐associated macrophage‐targeted biomimetic nano‐RBC to Reprogram tumor immunosuppressive microenvironment for enhanced …
Y Wang, J Yu, Z Luo, Q Shi, G Liu, F Wu… - Advanced …, 2021 - Wiley Online Library
Immunotherapy has shown encouraging results in various cancers, but the response rates
are relatively low due to the complex tumor immunosuppressive microenvironment (TIME) …
are relatively low due to the complex tumor immunosuppressive microenvironment (TIME) …
Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via Stat3 suppression
B Griess, S Mir, K Datta, M Teoh-Fitzgerald - Free Radical Biology and …, 2020 - Elsevier
Tumor associated macrophages (TAM) enhance the aggressiveness of breast cancer via
promoting cancer cell growth, metastasis, and suppression of the patient's immune system …
promoting cancer cell growth, metastasis, and suppression of the patient's immune system …
Predictors of responses to immune checkpoint blockade in advanced melanoma
Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical
armamentarium against metastatic melanoma (MMel). Given the frequency of immune …
armamentarium against metastatic melanoma (MMel). Given the frequency of immune …
A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international …
S Huet, B Tesson, JP Jais, AL Feldman… - The Lancet …, 2018 - thelancet.com
Background Patients with follicular lymphoma have heterogeneous outcomes. Predictor
models to distinguish, at diagnosis, between patients at high and low risk of progression are …
models to distinguish, at diagnosis, between patients at high and low risk of progression are …
TIGIT expression is associated with T-cell suppression and exhaustion and predicts clinical outcome and anti–PD-1 response in follicular lymphoma
Purpose: T-cell immunoglobulin and ITIM domain (TIGIT), a member of the immune
checkpoint family, is important in normal T-cell biology. However, the phenotypical profile …
checkpoint family, is important in normal T-cell biology. However, the phenotypical profile …
Role of tumor‐associated macrophages in human malignancies: friend or foe?
M Takeya, Y Komohara - Pathology international, 2016 - Wiley Online Library
Tumor‐associated macrophages (TAMs) play a pivotal role in tumor growth in human
malignancies. Published studies have analyzed the relationship between TAM infiltration …
malignancies. Published studies have analyzed the relationship between TAM infiltration …
The role of tumor-associated macrophages in hematologic malignancies
E Cencini, A Fabbri, A Sicuranza, A Gozzetti… - Cancers, 2021 - mdpi.com
Simple Summary Tumor-associated macrophages (TAM) represent a leading component of
the tumor microenvironment in hematologic malignancies. TAM could display antitumor …
the tumor microenvironment in hematologic malignancies. TAM could display antitumor …
Tumor-associated macrophages and response to 5-fluorouracil adjuvant therapy in stage III colorectal cancer
A Malesci, P Bianchi, G Celesti, G Basso… - …, 2017 - Taylor & Francis
Tumor-associated macrophages (TAMs) play a role in tumor development and progression.
We hypothesized that abundance of TAMs might modify efficacy of 5-fluorouracil …
We hypothesized that abundance of TAMs might modify efficacy of 5-fluorouracil …