T-2 toxin metabolism and its hepatotoxicity: New insights on the molecular mechanism and detoxification

W Song, Y Wang, T Huang, Y Liu, F Chen, Y Chen… - Environmental …, 2023 - Elsevier
T-2 toxin, a type A trichothecene, is a secondary metabolite produced by Fusarium poae,
Fusarium sporotrichioides, and Fusarium tricinctum. As the most toxic trichothecenes, T-2 …

Metal nanomaterials and hydrolytic enzyme-based formulations for improved antifungal activity

I Lyagin, A Aslanli, M Domnin, N Stepanov… - International Journal of …, 2023 - mdpi.com
Active research of metal-containing compounds and enzymes as effective antifungal agents
is currently being conducted due to the growing antifungal resistance problem. Metals are …

Synergistic antimicrobial action of lactoferrin-derived peptides and quorum quenching enzymes

A Aslanli, M Domnin, N Stepanov… - International Journal of …, 2023 - mdpi.com
Combined use of various antimicrobial peptides (AMPs) with enzymes that hydrolyze the
signaling molecules of the resistance mechanism of various microorganisms, quorum …

Cryo-EM structure and rational engineering of a superefficient ochratoxin A-detoxifying amidohydrolase

L Dai, D Niu, JW Huang, X Li, P Shen, H Li, Z **e… - Journal of Hazardous …, 2023 - Elsevier
Ochratoxin A (OTA) is among the most prevalent mycotoxins detected in agroproducts,
posing serious threats to human and livestock health. Using enzymes to conduct OTA …

Destruction of mycotoxins in poultry waste under anaerobic conditions within methanogenesis catalyzed by artificial microbial consortia

E Efremenko, O Senko, O Maslova, I Lyagin, A Aslanli… - Toxins, 2023 - mdpi.com
To reduce the toxicity of modern feeds polluted by mycotoxins, various sorbents are added
to them when feeding animals. A part of the mycotoxins is excreted from the body of animals …

Functional characterization and structural basis of an efficient ochratoxin A-degrading amidohydrolase

Y Hu, L Dai, Y Xu, D Niu, X Yang, Z **e, P Shen… - International Journal of …, 2024 - Elsevier
Ochratoxin A (OTA) contamination in various agro-products poses a serious threat to the
global food safety and human health, leading to enormous economic losses. Enzyme …

Not a mistake but a feature: Promiscuous activity of enzymes meeting mycotoxins

I Lyagin, N Stepanov, O Maslova, O Senko, A Aslanli… - Catalysts, 2022 - mdpi.com
Mycotoxins are dangerous compounds and find multiple routes to enter living bodies of
humans and animals. To solve the issue and degrade the toxicants,(bio) catalytic processes …

Carrier Variety Used in Immobilization of His6-OPH Extends Its Application Areas

E Efremenko, I Lyagin, A Aslanli, N Stepanov… - Polymers, 2023 - mdpi.com
Organophosphorus hydrolase, containing a genetically introduced hexahistidine sequence
(His6-OPH), attracts the attention of researchers by its promiscuous activity in hydrolytic …

Reassessing of enzymes degrading mycotoxins at acidic pH

I Lyagin, O Maslova, N Stepanov, O Senko… - International …, 2025 - Elsevier
Mycotoxins contaminate different commodities, thus endangering well being of humans and
animals. In the present study, three enzymes–peroxidase, laccase, and glucose oxidase …

Finite Element and Density Functional Theory Modeling Effectively Predict Pitting Degradation of Hydroxyapatite‐Coated Pure Magnesium

RA Dunne, DE Dickel, AM Green, D Kim… - … Research Part B …, 2024 - Wiley Online Library
The emergence of degradable orthopedic implants for fracture fixation may abrogate the
need for implant removal surgery and minimize pain associated with permanent implants …