[HTML][HTML] Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

M Sainz-Mejías, I Jurado-Martín, S McClean - Cells, 2020 - mdpi.com
Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with
cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and …

GM-CSF: orchestrating the pulmonary response to infection

TS McCormick, RB Hejal, LO Leal… - Frontiers in …, 2022 - frontiersin.org
This review summarizes the structure and function of the alveolar unit, comprised of alveolar
macrophage and epithelial cell types that work in tandem to respond to infection …

Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa

X Wang, C Liu, N Rcheulishvili, D Papukashvili, F **e… - npj Vaccines, 2023 - nature.com
Pseudomonas aeruginosa (PA) is a leading cause of hospital-acquired and ventilator-
associated pneumonia. The multidrug-resistance (MDR) rate of PA is increasing making the …

Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected …

J Luo, J Kong, B Dong, H Huang, K Wang… - Drug design …, 2016 - Taylor & Francis
Burgeoning antibiotic resistance and unfavorable outcomes of inflammatory injury after
Pseudomonas aeruginosa infection have necessitated the development of novel agents that …

Innate immune signaling activated by MDR bacteria in the airway

D Parker, D Ahn, T Cohen, A Prince - Physiological reviews, 2016 - journals.physiology.org
Health care-associated bacterial pneumonias due to multiple-drug resistant (MDR)
pathogens are an important public health problem and are major causes of morbidity and …

Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response

R Nickerson, CS Thornton, B Johnston… - Frontiers in …, 2024 - frontiersin.org
Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen capable of
exploiting barriers and immune defects to cause chronic lung infections in conditions such …

Receptors that inhibit macrophage activation: mechanisms and signals of regulation and tolerance

R Ocaña-Guzman, L Vázquez-Bolaños… - Journal of …, 2018 - Wiley Online Library
A variety of receptors perform the function of attenuating or inhibiting activation of cells in
which they are expressed. Examples of these kinds of receptors include TIM‐3 and PD‐1 …

LZ205, a newly synthesized flavonoid compound, exerts anti-inflammatory effect by inhibiting M1 macrophage polarization through regulating PI3K/AKT/mTOR …

D Bai, Y Zhao, Q Zhu, Y Zhou, Y Zhao, T Zhang… - Experimental cell …, 2018 - Elsevier
Macrophage polarization is involved in the process of inflammation. Regulation of
macrophage polarization is considered to be an effective method for the treatment of various …

[HTML][HTML] Current innovations in mRNA vaccines for targeting multidrug-resistant ESKAPE pathogens

S Imani, S Lv, H Qian, Y Cui, XY Li, A Babaeizad… - Biotechnology …, 2024 - Elsevier
The prevalence of multidrug-resistant (MDR) ESKAPE pathogens, including Enterococcus
faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and …

Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction

B Li, J Yin, J Chang, J Zhang, Y Wang… - Journal of …, 2021 - joe.bioscientifica.com
Microcirculatory injuries had been reported to be involved in diabetic cardiomyopathy, which
was mainly related to endothelial cell dysfunction. Apelin, an adipokine which is upregulated …