Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: The advances continue
The presence of N-heterocycles as an essential structural motif in a variety of biologically
active substances has stimulated the development of new strategies and technologies for …
active substances has stimulated the development of new strategies and technologies for …
Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological …
Nitrogen-rich heterocycles, particularly quinazolines and quinazolinones, represent a
unique class of diversified frameworks displaying a broad spectrum of biological functions …
unique class of diversified frameworks displaying a broad spectrum of biological functions …
Synthesis, biological evaluation and action mechanism of 7H-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-phenylhydrazone derivatives as α-glucosidase inhibitors
Q Feng, J Zhang, S Luo, Y Huang, Z Peng… - European Journal of …, 2023 - Elsevier
In our work, several 7H-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-phenylhydrazone
derivatives as α-glucosidase inhibitors (α-GIs) were synthesized and characterized by 1 H …
derivatives as α-glucosidase inhibitors (α-GIs) were synthesized and characterized by 1 H …
Triazolothiadiazoles and triazolothiadiazines as potent α-glucosidase inhibitors: Mechanistic insights from kinetics studies, molecular docking and dynamics …
Diabetes mellitus has been considered as a serious health problem worldwide due its high
prevalence rate and associated complications. In this context, the current research work …
prevalence rate and associated complications. In this context, the current research work …
Chemistry and biological activities of 1, 2, 4-triazolethiones—antiviral and anti-infective drugs
Mercapto-substituted 1, 2, 4-triazoles are very interesting compounds as they play an
important role in chemopreventive and chemotherapeutic effects on cancer. In recent …
important role in chemopreventive and chemotherapeutic effects on cancer. In recent …
New frontiers in the transition-metal-free synthesis of heterocycles from alkynoates: an overview and current status
Heterocycles are among the well-established classes of compounds, constituting a wide
range of organic molecules. These structural motifs not only have a dominant presence in a …
range of organic molecules. These structural motifs not only have a dominant presence in a …
Hybrid quinoline-thiosemicarbazone therapeutics as a new treatment opportunity for Alzheimer's disease‒synthesis, in vitro cholinesterase inhibitory potential and …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading
cause of dementia worldwide. The limited pharmacological approaches based on …
cause of dementia worldwide. The limited pharmacological approaches based on …
Thiadiazole inhibitors: a patent review
Introduction: Four isomeric structures of thiadiazole motifs have outstanding
pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is …
pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is …
Design and synthesis of new bis (1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazines) and bis ((quinoxalin-2-yl) phenoxy) alkanes as anti-breast cancer agents through dual …
A number of new 1, ω-bis ((acetylphenoxy) acetamide) alkanes 5a–f were prepared then
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …