This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …

Over the last decade, many catalytically active DNA molecules (deoxyribozymes; DNA
enzymes) have been identified by in vitro selection from random-sequence DNA pools. This …

In addition to storage of genetic information, DNA can also catalyze various reactions. RNA-
cleaving DNAzymes are the catalytic DNAs discovered the earliest, and they can cleave …

Materials: dAimTP was synthesized according to a literature procedure [1] and dUaaTP was
purchased from Sigma-Aldrich. All oligonucleotides were purchased from Integrated DNA …

In cells, DNA typically consists of two antiparallel strands arranged in a double-helical
structure, which is central to its fundamental role in storing and transmitting genetic …

DNA (deoxyribonucleic acid) is the genetic material common to all of Earth's organisms. Our
biological understanding of DNA is extensive and well‐exploited. In recent years, chemists …

One of the chemist's key motivations is to explore the forefront of catalysis. In this Account,
we describe our laboratory's efforts at one such forefront: the use of DNA as a catalyst …

The discovery of naturally occurring catalytic RNA (RNA enzymes, or ribozymes) in the
1980s immediately revised the view of RNA as a passive messenger that solely carries …

DNA and RNA nucleobase modifications are biologically relevant and valuable in
fundamental biochemical and biophysical investigations of nucleic acids. However, directly …

After transcription of a eukaryotic pre‐mRNA, its introns are removed by the spliceosome,
joining exons for translation. The intron products of splicing have long been considered …