Background Adult mesenchymal stem cells (MSCs) hold great promise for regenerative
medicine because of their self-renewal, multipotency, and trophic and immunosuppressive …

Aplastic anemia (AA) is characterized by bone marrow (BM) hypocellularity, resulting in
peripheral cytopenias. An antigen-driven and likely auto-immune dysregulated T-cell …

Stem cells play a crucial role in re-establishing homeostasis in the body, and the search for
mechanisms by which they interact with the host to exert their therapeutic effects remains a …

Background Longitudinal studies have verified the pivotal role of mesenchymal stem/stromal
cells (MSCs) in the bone marrow microenvironment for hematopoiesis and coordinate …

The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells
(HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into …

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune
tolerance, whereby the immune cells attack self-antigens causing pain and inflammation …

Background Mesenchymal stem/stromal cells (MSCs) derived from human embryonic stem
cells (hESCs) are attractive for their hematopoietic-supporting or potential therapeutic …

Aplastic anemia (AA), a rare but potentially life-threatening disease, is a paradigm of bone
marrow failure syndromes characterized by pancytopenia in the peripheral blood and …

Human culture‐expanded mesenchymal stromal cells (MSC) are being considered for
multiple therapeutic applications because of their regenerative and anti‐inflammatory …

Over the past two decades, there has been an explosion in the numbers of clinical trials
using mesenchymal stem cells (MSCs). While the safety profile of MSC therapy has been …