The past couple of years have seen several novel X-ray structures of 7 transmembrane
(7TM) receptors in complex with antagonists and even with a peptide fragment of a G …

Several new pairs of active and inactive GPCR structures have recently been solved
enabling detailed structural insight into the activation process, not only of rhodopsin but now …

Abstract Thyroid-stimulating hormone (TSH), through activation of its G-protein-coupled
thyrotropin receptor (TSHR), controls the synthesis of thyroid hormone—an essential …

Invertebrate phototransduction uses an inositol-1, 4, 5-trisphosphate signalling cascade in
which photoactivated rhodopsin stimulates a Gq-type G protein, that is, a class of G protein …

A major obstacle to understanding the functional importance of dimerization between class
AG protein–coupled receptors (GPCRs) has been the methodological limitation in achieving …

The conserved tryptophan in position 13 of TM-VI (Trp-VI: 13 or Trp-6.48) of the CWXP motif
located at the bottom of the main ligand-binding pocket in TM-VI is believed to function as a …

The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of
family AG protein-coupled receptors. The TSHR is of great importance for the growth and …

The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone
receptors, a sub-group of class A G-protein-coupled receptors (GPCRs). TSHR and its …

G protein–coupled receptors (GPCRs) respond to a chemically diverse plethora of signal
transduction molecules. The notion that GPCRs also signal without an external chemical …

The adenosine A 2A receptor (A 2A R) is a G-protein-coupled receptor that plays a key role
in transmembrane signalling mediated by the agonist adenosine. The structure of A 2A R …