Immune modulation through the intracellular delivery of nucleoside-modified mRNA to
immune cells is an attractive approach for in vivo immunoengineering, with applications in …

Introduction Immunotherapy has revolutionized cancer treatment by harnessing the immune
system to enhance antitumor responses while minimizing off-target effects. Among the …

Lipid nanoparticles (LNPs) play a crucial role in addressing genetic disorders, and cancer,
and combating pandemics such as COVID-19 and its variants. Yet, the ability of LNPs to …

Despite the great potential of DNA vaccines for a broad range of applications, ranging from
prevention of infections, over treatment of autoimmune and allergic diseases to cancer …

COVID-19, stemming from the SARS-CoV-2 virus, has initiated a worldwide respiratory
pandemic. Remarkable headway has been made in the realm of vaccination, as nearly …

Advances in gene therapy, exemplified by mRNA vaccines against COVID-19, highlight the
importance of lipid nanoparticles (LNPs) for nucleic acid delivery despite challenging …

The value of lipid nanoparticles (LNPs) for delivery of messenger RNA (mRNA) was
demonstrated by the coronavirus disease 2019 (COVID-19) mRNA vaccines, but the ability …

In 2009, a novel swine-origin H1N1 virus emerged, causing a pandemic. The virus, known
as H1N1pdm09, quickly displaced the circulating H1 lineage and became the dominant …

The effectiveness of mRNA vaccines largely depends on their lipid nanoparticle (LNP)
component. Herein, we investigate the effectiveness of DLin-KC2-DMA (KC2) and SM-102 …

Advancements in cancer immunotherapy have been notable; however, challenges remain
regarding precision and the capacity to generate robust immune responses. This review …