Most adaption processes have a polygenic genetic basis, but even with the recent explosive
growth of genomic data we are still lacking a unified framework describing the dynamics of …

Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …

The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …

Chromosomal inversions are an important form of structural variation that can affect
recombination, chromosome structure and fitness. However, because inversions can be …

How locally adapted ecotypes are established and maintained within a species is a long-
standing question in evolutionary biology. Using forest and prairie ecotypes of deer mice …

Low‐coverage whole genome sequencing (lcWGS) has emerged as a powerful and cost‐
effective approach for population genomic studies in both model and nonmodel species …

Chromosomal inversions have long fascinated evolutionary biologists due to their
suppression of recombination, which can protect co-adapted alleles. Emerging research …

Signals of local adaptation have been found in many plants and animals, highlighting the
heterogeneity in the distribution of adaptive genetic variation throughout species ranges. In …

The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …

Decrypting the rearrangements that drive mammalian chromosome evolution is critical to
understanding the molecular bases of speciation, adaptation, and disease susceptibility …