Red blood cell metabolism in vivo and in vitro
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
Red blood cell omics and machine learning in transfusion medicine: singularity is near
A D'Alessandro - Transfusion Medicine and Hemotherapy, 2023 - karger.com
Background: Blood transfusion is a life-saving intervention for millions of recipients
worldwide. Over the last 15 years, the advent of high-throughput, affordable omics …
worldwide. Over the last 15 years, the advent of high-throughput, affordable omics …
In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction
Despite a wealth of exploratory plasma metabolomics studies in sickle cell disease (SCD),
no study to date has evaluate a large and well phenotyped cohort to compare the primary …
no study to date has evaluate a large and well phenotyped cohort to compare the primary …
Omics markers of platelet transfusion in trauma patients
Background Even in the era of the COVID‐19 pandemic, trauma remains the global leading
cause of mortality under the age of 49. Trauma‐induced coagulopathy is a leading driver of …
cause of mortality under the age of 49. Trauma‐induced coagulopathy is a leading driver of …
Omics markers of red blood cell transfusion in trauma
Red blood cell (RBC) transfusion is a life-saving intervention for millions of trauma patients
every year worldwide. While hemoglobin thresholds are clinically driving the need for RBC …
every year worldwide. While hemoglobin thresholds are clinically driving the need for RBC …
Omics technologies in veterinary medicine: literature review and perspectives in transfusion medicine
A Miglio, V Cremonini, L Leonardi, E Manuali… - Transfusion Medicine …, 2023 - karger.com
Background: Omics technologies represent a new analytical approach that allows a full
cellular readout through the simultaneous analysis of thousands of molecules. The …
cellular readout through the simultaneous analysis of thousands of molecules. The …
[HTML][HTML] Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment
Metabolomics studies in sickle cell disease (SCD) have been so far limited to tens of
samples, owing to technical and experimental limitations. To overcome these limitations, we …
samples, owing to technical and experimental limitations. To overcome these limitations, we …
Biological and clinical factors contributing to the metabolic heterogeneity of hospitalized patients with and without COVID-19
The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide
challenge. The present large study sought to understand independent and overlap** …
challenge. The present large study sought to understand independent and overlap** …
ZOOMICS: comparative metabolomics of red blood cells from Guinea pigs, humans, and non-human primates during refrigerated storage for up to 42 days
L Bertolone, HKH Shin, JH Baek, Y Gao… - Frontiers in …, 2022 - frontiersin.org
Unlike other rodents, guinea pigs (Cavia porcellus) have evolutionarily lost their capacity to
synthesize vitamin C (ascorbate) de novo and, like several non-human primates and …
synthesize vitamin C (ascorbate) de novo and, like several non-human primates and …
Omics signatures of tissue injury and hemorrhagic shock in swine
Objective: Advanced mass spectrometry methods were leveraged to analyze both
proteomics and metabolomics signatures in plasma upon controlled tissue injury (TI) and …
proteomics and metabolomics signatures in plasma upon controlled tissue injury (TI) and …