Polymeric nanoparticles for drug delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects

E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives

R Sun, J **ang, Q Zhou, Y Piao, J Tang, S Shao… - Advanced drug delivery …, 2022 - Elsevier
Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …

Advances in nanomaterial-based targeted drug delivery systems

X Cheng, Q **e, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …

Ultrasound-based micro-/nanosystems for biomedical applications

H Huang, Y Zheng, M Chang, J Song, L **a… - Chemical …, 2024 - ACS Publications
Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time
capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been …

A translational framework to DELIVER nanomedicines to the clinic

P Joyce, CJ Allen, MJ Alonso, M Ashford… - Nature …, 2024 - nature.com
Nanomedicines have created a paradigm shift in healthcare. Yet fundamental barriers still
exist that prevent or delay the clinical translation of nanomedicines. Critical hurdles …

Gold complexes in anticancer therapy: from new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Strategies for delivering therapeutics across the blood–brain barrier

GC Terstappen, AH Meyer, RD Bell… - Nature Reviews Drug …, 2021 - nature.com
Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

[HTML][HTML] Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

M Ghezzi, S Pescina, C Padula, P Santi… - Journal of Controlled …, 2021 - Elsevier
Polymeric micelles, ie aggregation colloids formed in solution by self-assembling of
amphiphilic polymers, represent an innovative tool to overcome several issues related to …

Cancer nanomedicine toward clinical translation: Obstacles, opportunities, and future prospects

P Zhang, Y **ao, X Sun, X Lin, S Koo, AV Yaremenko… - Med, 2023 - cell.com
With the integration of nanotechnology into the medical field at large, great strides have
been made in the development of nanomedicines for tackling different diseases, including …