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Abietic acid antagonizes the anti-inflammatory effects of celecoxib and ketoprofen: Preclinical assessment and molecular dynamic simulations
The present work is designed to explore the anti-inflammatory properties of AA and its
modulatory effects on celecoxib (CEL) and ketoprofen (KET) through in vitro, ex vivo, in vivo …
modulatory effects on celecoxib (CEL) and ketoprofen (KET) through in vitro, ex vivo, in vivo …
Phytol exerts sedative-like effects and modulates the diazepam and flumazenil's action, possibly through the GABAA receptor interaction pathway
This study aimed at the evaluation of the sedative effect of phytol (PHY) with possible
molecular mechanisms through in vivo and in silico studies. For this, adult male mice were …
molecular mechanisms through in vivo and in silico studies. For this, adult male mice were …
Tangeretin exerts and modulates the anxiolytic effects of the GABAkine drugs diazepam and flumazenil in mice: Molecular interventions through animal behavior and …
The citrus peel flavonoid tangeretin (TAN) has diverse biological activities, including
antioxidant, anti-inflammatory, anti-tumor, hepatoprotective, and neuroprotective effects. This …
antioxidant, anti-inflammatory, anti-tumor, hepatoprotective, and neuroprotective effects. This …
Trans-Ferulic acid reduces the sedative activity of diazepam in thiopental sodium-induced slee** mice: A potential GABAergic transmission
Abstract trans-Ferulic acid (TFA), a bioactive compound found in many plants, has been
recognized for its diverse pharmacological activities, including potential neurological …
recognized for its diverse pharmacological activities, including potential neurological …
Anxiogenic-like effects of coumarin, possibly through the GABAkine interaction pathway: Animal studies with in silico approaches
AAS Prottay, TR Ripu, MN Sarwar, T Rahman… - Behavioural Brain …, 2025 - Elsevier
Background Anxiety disorder is the most common mental illness and a major contributor to
impairment. Thus, there is an urgent need to find novel lead compounds to mitigate anxiety …
impairment. Thus, there is an urgent need to find novel lead compounds to mitigate anxiety …
[HTML][HTML] GABAA Receptors Are Involved in the Seizure Blockage Prompted by a Polyphenol-Rich Extract of White Grape Juice in Rodents
Background/Objectives: Polyphenols have been suggested to possess anticonvulsant
properties, which can be exploited as tools in novel strategies against epilepsy. Along that …
properties, which can be exploited as tools in novel strategies against epilepsy. Along that …
Exploring the Antiemetic Potential of Caffeic Acid: A Combined In Vivo and Computational Approach
Background This study emphasizes evaluating the antiemetic efficacy of the natural food
component caffeic acid (CAF) using a copper sulfate pentahydrate (CuSO4. 5H2O)‐induced …
component caffeic acid (CAF) using a copper sulfate pentahydrate (CuSO4. 5H2O)‐induced …
Synergistic Anxiolytic Effects of Linalool and Sesamol Co‐Treatment on Swiss Albino Mice: A Potential GABAergic Intervention
Sesamol (SES) and linalool (LIN) are aromatic compounds that have neuroprotective effects.
The main purpose of this study is to evaluate the anxiolytic activity of LIN and SES co …
The main purpose of this study is to evaluate the anxiolytic activity of LIN and SES co …