Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …

Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of
glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that …

The circadian clock regulates daily rhythms of numerous physiological activities through
tightly coordinated modulation of gene expression and biochemical functions. Circadian …

Glioblastoma (GBM) is an aggressive and lethal type of brain tumor in human adults. The
standard of care offers minimal clinical benefit, and most GBM patients experience tumor …

Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …

Glioblastoma (GBM) is one of the most aggressive tumors in the adult central nervous
system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects …

Glioma is a mixed solid tumor composed of neoplastic and non-neoplastic components.
Glioma-associated macrophages and microglia (GAMs) are crucial elements of the glioma …

Glioblastoma (GBM) is a hypoxic and" immune-cold" tumor containing rich stromal signaling
molecules and cell populations, such as proteases and immunosuppressive tumor …