Nitric oxide (NO) methodology is a complex and often confusing science and the focus of
many debates and discussion concerning NO biochemistry. NO is involved in many …

A continuous supply of oxygen is essential for the survival of multicellular organisms. The
understanding of how this supply is regulated in the microvasculature has evolved from …

N-Nitrosamines are a class of compounds notorious both for the potent carcinogenicity of
many of its members and for their widespread occurrence throughout the human …

Protein S-nitrosylation, the posttranslational modification of cysteine thiols to form S-
nitrosothiols, is a principle mechanism of nitric oxide-based signaling. Studies have …

RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always
improve oxygen delivery and is associated with ischemic events. We hypothesized that …

Rationale: Stroke is the third most common cause of death in industrialized countries. The
main therapeutic target is the ischemic penumbra, potentially salvageable brain tissue that …

Emerging evidence strongly suggests that dietary nitrate, derived in the diet primarily from
vegetables, could contribute to cardiovascular health via effects on nitric oxide (NO) status …

The rate that hemoglobin reacts with nitric oxide (NO) is limited by how fast NO can diffuse
into the heme pocket. The reaction is as fast as any ligand/protein reaction can be and the …

Background—It has been proposed that under hypoxic conditions, nitrite may release nitric
oxide, which causes potent vasodilation. We hypothesized that nitrite would have a greater …

Nitric oxide (NO) is a signal molecule and plays a critical role in the regulation of vascular
tone, displays anti-platelet and anti-inflammatory properties. While our earlier and current …