Excessive daytime sleepiness in obstructive sleep apnea. Mechanisms and clinical management

C Lal, TE Weaver, CJ Bae, KP Strohl - Annals of the American …, 2021 - atsjournals.org
Many patients with obstructive sleep apnea (OSA) experience excessive daytime sleepiness
(EDS), which can negatively affect daily functioning, cognition, mood, and other aspects of …

Obstructive sleep apnea, cognition and Alzheimer's disease: a systematic review integrating three decades of multidisciplinary research

OM Bubu, AG Andrade, OQ Umasabor-Bubu… - Sleep medicine …, 2020 - Elsevier
Increasing evidence links cognitive-decline and Alzheimer's disease (AD) to various sleep
disorders, including obstructive sleep apnea (OSA). With increasing age, there are …

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's …

MA Daulatzai - Journal of neuroscience research, 2017 - Wiley Online Library
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Modifiable factors that alter the size of the hippocampus with ageing

M Fotuhi, D Do, C Jack - Nature Reviews Neurology, 2012 - nature.com
The hippocampus is particularly vulnerable to the neurotoxic effects of obesity, diabetes
mellitus, hypertension, hypoxic brain injury, obstructive sleep apnoea, bipolar disorder …

Objective measurement of sleep in mild cognitive impairment: a systematic review and meta-analysis

AL D'Rozario, JL Chapman, CL Phillips… - Sleep Medicine …, 2020 - Elsevier
Older adults with mild cognitive impairment (MCI) are at-risk of develo** dementia,
particularly Alzheimer's disease. While some research suggests that alterations in sleep …

Memory and obstructive sleep apnea: a meta-analysis

A Wallace, RS Bucks - Sleep, 2013 - academic.oup.com
Abstract Study Objectives: To examine episodic memory performance in individuals with
obstructive sleep apnea (OSA). Design Meta-analysis was used to synthesize results from …

Cognition and daytime functioning in sleep-related breathing disorders

ML Jackson, ME Howard, M Barnes - Progress in brain research, 2011 - Elsevier
Sleep-related breathing disorders encompass a range of disorders in which abnormal
ventilation occurs during sleep as a result of partial or complete obstruction of the upper …

Update on persistent excessive daytime sleepiness in OSA

S Javaheri, S Javaheri - Chest, 2020 - Elsevier
OSA is a highly prevalent sleep disorder, and subjective excessive daytime sleepiness
(EDS) is the cardinal symptom for which many individuals seek medical advice. Positive …

Effect of CPAP on cognition, brain function, and structure among elderly patients with OSA: a randomized pilot study

M Dalmases, C Solé-Padullés, M Torres, C Embid… - Chest, 2015 - Elsevier
BACKGROUND Despite the increasing aging population and the high prevalence of OSA in
elderly adults, little is known about cognitive effects of OSA and the effectiveness of CPAP …

Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea

R Kumar, AS Chavez, PM Macey… - Journal of …, 2012 - Wiley Online Library
Obstructive sleep apnea (OSA) is a common and progressive disorder accompanied by
severe cardiovascular and neuropsychological sequelae, presumably induced by brain …