A comprehensive review of N-heterocycles as cytotoxic agents
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: search for anticancer agent
The synthesis of some 2-furano-4 (3H)-quinazolinones, diamides (open ring quinazolines),
quinoxalines and their biological evaluation as antitumor agents using National Cancer …
quinoxalines and their biological evaluation as antitumor agents using National Cancer …
Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors
ML de Castro Barbosa, LM Lima, R Tesch… - European journal of …, 2014 - Elsevier
Abstract Novel 2-chloro-4-anilino-quinazolines designed as EGFR and VEGFR-2 dual
inhibitors were synthesized and evaluated for inhibitory effects. EGFR and VEGFR-2 are …
inhibitors were synthesized and evaluated for inhibitory effects. EGFR and VEGFR-2 are …
Therapeutic applications of lipoic acid: a patent review (2011–2014)
M Koufaki - Expert opinion on therapeutic patents, 2014 - Taylor & Francis
Introduction: Lipoic acid (LA), a naturally occurring 1, 2-dithiolane analog that plays an
essential role in mitochondrial bioenergetic reactions, has gained unprecedented attention …
essential role in mitochondrial bioenergetic reactions, has gained unprecedented attention …
Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2
HQ Zhang, FH Gong, JQ Ye, C Zhang, XH Yue… - European Journal of …, 2017 - Elsevier
EGFR and VEGFR-2 are involved in pathological disorders and the progression of different
kinds of tumors, the combined blockade of EGFR and VEGFR signaling pathways appears …
kinds of tumors, the combined blockade of EGFR and VEGFR signaling pathways appears …
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease
M Rosini, E Simoni, M Bartolini, A Tarozzi… - European journal of …, 2011 - Elsevier
Lipoic acid (LA) is a natural antioxidant. Its structure was previously combined with that of
the acetylcholinesterase inhibitor tacrine to give lipocrine (1), a lead compound …
the acetylcholinesterase inhibitor tacrine to give lipocrine (1), a lead compound …
New series of 4, 6-diaryl pyrimidines: facile synthesis and antiproliferative activity as dual EGFR/VEGFR-2 inhibitors
Introduction We developed and produced a new series of 4, 6-diaryl-pyrimidines 9–29 as
antiproliferative agents targeting EGFR/VEGFR-2. Methods The antiproliferative efficacy of …
antiproliferative agents targeting EGFR/VEGFR-2. Methods The antiproliferative efficacy of …
Epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors
A number of new compounds bearing two ortho-bromo-and ortho, ortho-dibromophenol
moieties linked through a saturated/unsaturated, linear/(poly) cyclic spacer (compounds 1 …
moieties linked through a saturated/unsaturated, linear/(poly) cyclic spacer (compounds 1 …
Novel thienopyrimidine derivatives as dual EGFR and VEGFR-2 inhibitors: design, synthesis, anticancer activity and effect on cell cycle profile
Aim: Design and synthesis of thienopyrimidine derivatives as dual EGFR and VEGFR-2
inhibitors. Material and methods: A series of novel 6, 7, 8, 9-tetrahydro-5 H-cyclohepta [4, 5] …
inhibitors. Material and methods: A series of novel 6, 7, 8, 9-tetrahydro-5 H-cyclohepta [4, 5] …
Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase
Two series of new 6-alkoxy-4-substituted-aminoquinazolines (2–4f) and their bioisoteric
quinoline congeners (5–7c) were designed and synthesized. Virtual screening was carried …
quinoline congeners (5–7c) were designed and synthesized. Virtual screening was carried …