Generative models as an emerging paradigm in the chemical sciences

DM Anstine, O Isayev - Journal of the American Chemical Society, 2023 - ACS Publications
Traditional computational approaches to design chemical species are limited by the need to
compute properties for a vast number of candidates, eg, by discriminative modeling …

Applications of single-cell RNA sequencing in drug discovery and development

B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles

I Rauluseviciute, R Riudavets-Puig… - Nucleic acids …, 2024 - academic.oup.com
Abstract JASPAR (https://jaspar. elixir. no/) is a widely-used open-access database
presenting manually curated high-quality and non-redundant DNA-binding profiles for …

[HTML][HTML] AI for life: Trends in artificial intelligence for biotechnology

A Holzinger, K Keiblinger, P Holub, K Zatloukal… - New biotechnology, 2023 - Elsevier
Due to popular successes (eg, ChatGPT) Artificial Intelligence (AI) is on everyone's lips
today. When advances in biotechnology are combined with advances in AI unprecedented …

COSMIC: a curated database of somatic variants and clinical data for cancer

Z Sondka, NB Dhir, D Carvalho-Silva… - Nucleic Acids …, 2024 - academic.oup.com
Abstract The Catalogue Of Somatic Mutations In Cancer (COSMIC), https://cancer. sanger.
ac. uk/cosmic, is an expert-curated knowledgebase providing data on somatic variants in …

RCSB Protein Data Bank (RCSB. org): delivery of experimentally-determined PDB structures alongside one million computed structure models of proteins from …

SK Burley, C Bhikadiya, C Bi, S Bittrich… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB), founding member of the Worldwide Protein Data Bank (wwPDB), is the US data center …

Introducing the bacterial and viral bioinformatics resource center (BV-BRC): a resource combining PATRIC, IRD and ViPR

RD Olson, R Assaf, T Brettin, N Conrad… - Nucleic acids …, 2023 - academic.oup.com
Abstract The National Institute of Allergy and Infectious Diseases (NIAID) established the
Bioinformatics Resource Center (BRC) program to assist researchers with analyzing the …

The ProteomeXchange consortium at 10 years: 2023 update

EW Deutsch, N Bandeira, Y Perez-Riverol… - Nucleic acids …, 2023 - academic.oup.com
Mass spectrometry (MS) is by far the most used experimental approach in high-throughput
proteomics. The ProteomeXchange (PX) consortium of proteomics resources (http://www …

NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update

E Clough, T Barrett, SE Wilhite, P Ledoux… - Nucleic acids …, 2024 - academic.oup.com
Abstract The Gene Expression Omnibus (GEO) is an international public repository that
archives gene expression and epigenomics data sets generated by next-generation …

Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …