The link between circulating follicular helper T cells and autoimmunity
LSK Walker - Nature Reviews Immunology, 2022 - nature.com
Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …
centres that allow affinity maturation of antibody responses. Although usually located in …
Abdominal aortic aneurysm: roles of inflammatory cells
Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …
[HTML][HTML] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination
SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen …
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen …
SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation
The deployment of effective vaccines against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (COVID …
coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (COVID …
Cytokine-skewed Tfh cells: functional consequences for B cell help
AC Olatunde, JS Hale, TJ Lamb - Trends in immunology, 2021 - cell.com
CD4+ follicular helper T (Tfh) cells play a vital role in providing help for B cells undergoing
selection and differentiation into activated antibody-secreting cells in mammalian germinal …
selection and differentiation into activated antibody-secreting cells in mammalian germinal …
Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases
The interactions of CD4+ T cells and B cells are fundamental for the generation of protective
antibody responses, as well as for the development of harmful autoimmune diseases …
antibody responses, as well as for the development of harmful autoimmune diseases …
[HTML][HTML] PI3K signalling in inflammation
PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …
Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells
The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in
tissues, is key for a broad range of immunological research, including vaccine responses …
tissues, is key for a broad range of immunological research, including vaccine responses …
Pathophysiology of T follicular helper cells in humans and mice
Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that
induce the differentiation of B cells into plasma cells and memory cells. They are found …
induce the differentiation of B cells into plasma cells and memory cells. They are found …
T follicular helper cells in autoimmune disorders
T follicular helper (Tfh) cells are a distinct subset of CD4+ T lymphocytes, specialized in B
cell help and in regulation of antibody responses. They are required for the generation of …
cell help and in regulation of antibody responses. They are required for the generation of …