The Src, Syk, and Tec family kinases are three of the most well characterized tyrosine kinase
families found in the human genome. Members of these kinase families function …

The Tec family tyrosine kinases regulate lymphocyte development, activation, and
differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of …

Protein conformational switches alter their shape upon receiving an input signal, such as
ligand binding, chemical modification, or change in environment. The apparent simplicity of …

Simple Summary Proline isomerization influences protein folding and function tremendously
and serves as a unique type of post-translational modification that regulates multiple …

We present a program, named Promega, to predict the Xaa-Pro peptide bond conformation
on the basis of backbone chemical shifts and the amino acid sequence. Using a chemical …

The assembly of complexes following the detection of extracellular signals is often controlled
by signaling proteins comprising multiple peptide binding modules. The SRC homology …

SH2 domains are long known prominent players in the field of phosphotyrosine recognition
within signaling protein networks. However, over the years they have been joined by an …

Cellular functions require specific protein-protein interactions that are often mediated by
modular domains that use binding pockets to engage particular sequence motifs in their …

Proline switches, controlled by cis-trans isomerization, have emerged as a particularly
effective regulatory mechanism in a wide range of biological processes. Here we report the …

Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T
cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor …