Members of the nuclear receptor superfamily of ligand-dependent transcription factors
regulate diverse aspects of immunity and inflammation by both positively and negatively …

IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in
host defence against bacterial and fungal infections, as well as in the pathogenesis of …

T helper cells secreting interleukin (IL)-17 (Th17 cells) play a crucial role in autoimmune
diseases like multiple sclerosis (MS). Th17 differentiation, which is induced by a …

The Ca2+ dependent transcription factor family known as nuclear factor of activated T cells
(NFAT) has been shown to be important in T-cell immune responses. Because NFAT …

Th17 cells are a subset of CD4+ T cells with an important role in clearing certain bacterial
and fungal pathogens. However, they have also been implicated in autoimmune diseases …

Estrogen treatment exerts a protective effect on experimental autoimmune
encephalomyelitis (EAE) and is under clinical trial for multiple sclerosis therapy. Estrogens …

Over the last decade, our understanding of helper/effector T cell differentiation has changed
dramatically. The discovery of interleukin (IL-) 17-producing T cells (Th17) and other subsets …

Summary T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections,
yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown …

Aryl hydrocarbon receptor (AHR) plays critical roles in various autoimmune diseases such
as multiple sclerosis by controlling interleukin-17 (IL-17)–producing T-helper (TH17) and …

The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …