The multidisciplinary management of rectal cancer

DS Keller, M Berho, RO Perez, SD Wexner… - Nature Reviews …, 2020‏ - nature.com
Rectal cancer treatment has evolved during the past 40 years with the use of a standardized
surgical technique for tumour resection: total mesorectal excision. A dramatic reduction in …

Future direction of total neoadjuvant therapy for locally advanced rectal cancer

Y Kagawa, JJ Smith, E Fokas, J Watanabe… - Nature Reviews …, 2024‏ - nature.com
Despite therapeutic advancements, disease-free survival and overall survival of patients
with locally advanced rectal cancer have not improved in most trials as a result of distant …

Rectal cancer, version 2.2022, NCCN clinical practice guidelines in oncology

AB Benson, AP Venook, MM Al-Hawary, N Azad… - Journal of the National …, 2022‏ - jnccn.org
This selection from the NCCN Guidelines for Rectal Cancer focuses on management of
malignant polyps and resectable nonmetastatic rectal cancer because important updates …

Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy

J Garcia-Aguilar, S Patil, MJ Gollub, JK Kim… - Journal of Clinical …, 2022‏ - ascopubs.org
PURPOSE Prospective data on the efficacy of a watch-and-wait strategy to achieve organ
preservation in patients with locally advanced rectal cancer treated with total neoadjuvant …

Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for patients with locally advanced rectal cancer: long-term results of …

E Fokas, A Schlenska-Lange, B Polat, G Klautke… - JAMA …, 2022‏ - jamanetwork.com
Importance Total neoadjuvant therapy has been increasingly adopted for multimodal rectal
cancer treatment. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy …

The American Society of Colon and Rectal Surgeons clinical practice guidelines for the management of rectal cancer

YN You, KM Hardiman, A Bafford, V Poylin… - Diseases of the Colon …, 2020‏ - journals.lww.com
The American Society of Colon and Rectal Surgeons (ASCRS) is dedicated to ensuring high-
quality patient care by advancing the science, prevention, and management of disorders …

Randomized phase II trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: CAO …

E Fokas, M Allgäuer, B Polat, G Klautke… - Journal of Clinical …, 2019‏ - ascopubs.org
PURPOSE Total neoadjuvant therapy is a new paradigm for rectal cancer treatment. Optimal
scheduling of preoperative chemoradiotherapy (CRT) and chemotherapy remains to be …

A rectal cancer organoid platform to study individual responses to chemoradiation

K Ganesh, C Wu, KP O'Rourke, BC Szeglin, Y Zheng… - Nature medicine, 2019‏ - nature.com
Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation
and surgery to optimize outcomes for individual patients. No accurate model of RC exists to …

[HTML][HTML] Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

R Glynne-Jones, L Wyrwicz, E Tiret, G Brown… - Annals of …, 2017‏ - Elsevier
The incidence of rectal cancer in the European Union is∼ 125 000 per year, ie∼ 35% of the
total colorectal cancer incidence, reflecting 15–25 cases/100 000 population per year and is …

Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy

JJ Smith, P Strombom, OS Chow, CS Roxburgh… - JAMA …, 2019‏ - jamanetwork.com
Importance The watch-and-wait (WW) strategy aims to spare patients with rectal cancer
unnecessary resection. Objective To analyze the outcomes of WW among patients with …