Hemostasis and fibrinolysis, the biological processes that maintain proper blood flow, are
the consequence of a complex series of cascading enzymatic reactions. Serine proteases …

SERPIN (serine proteinase inhibitors) is an acronym for the superfamily of structurally similar
proteins found in animals, plants, bacteria, viruses, and archaea. Over 1500 SERPINs are …

Repeating intermolecular protein association by means of β-sheet expansion is the
mechanism underlying a multitude of diseases including Alzheimer's, Huntington's and …

Pediatric thromboembolism (≤ 18 years) is very rare (0.07-0.14/10,000/year) but may be
more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin …

Essentials• We investigated the molecular base of antithrombin deficiency in cases without
SERPINC1 defects.• 27% of cases presented hypoglycosylation, transient in 62% and not …

Inherited deficiencies of natural anticoagulants such as antithrombin (AT; gene: SERPINC1),
protein C (PC; PROC), and protein S (PS; PROS1), with the prevalence in the general …

Antithrombin, a major endogenous anticoagulant, is a serine protease inhibitor (serpin). We
characterized the biological and clinical impact of variants involving C-terminal antithrombin …

Serine protease inhibitors (serpins) include thousands of structurally conserved proteins
playing key roles in many organisms. Mutations affecting serpins may disturb their …

The key haemostatic role of antithrombin and the risk of thrombosis associated with its
deficiency support that the low incidence of antithrombin deficiency among patients with …

The balance between actions of procoagulant and anticoagulant factors protects organisms
from bleeding and thrombosis. Thus, antithrombin deficiency increases the risk of …