A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and
protects the microvasculature from potentially harmful fluctuations in pressure and blood …

Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

Medial vascular calcification has emerged as a putative key factor contributing to the
excessive cardiovascular mortality of patients with chronic kidney disease (CKD) …

Laurent et al Early, Normal, and Supernormal Vascular Aging 219 normally defined by the
absence of variables linked to the metabolic syndrome. 21, 22 An alternative way to define …

Arterial stiffness is a major independent risk factor for cardiovascular complications causing
isolated systolic hypertension and increased pulse pressure in the microvasculature of …

538 Hypertension September 2018 or near normal LV ejection fractions, consistent with the
clinical picture of HFpEF. In the I-PRESERVE study (Irbesartan in Heart Failure With …

MicroRNAs (miRNAs) are epigenetic regulators that can target and inhibit translation of
multiple mRNAs within a given cell type. As such, a number of different pathways and …

Aging of the microcirculatory network plays a central role in the pathogenesis of a wide
range of age-related diseases, from heart failure to Alzheimer's disease. In the eye, changes …

Vascular calcification (VC), characterized by different mineral deposits (ie, carbonate apatite,
whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a …

Elastin provides recoil to tissues that stretch such as the lung, blood vessels, and skin. It is
deposited in a brief window starting in the prenatal period and extending to adolescence in …