The evolution of gene duplications: classifying and distinguishing between models
Gene duplications and their subsequent divergence play an important part in the evolution
of novel gene functions. Several models for the emergence, maintenance and evolution of …
of novel gene functions. Several models for the emergence, maintenance and evolution of …
Antigen presentation in cancer—mechanisms and clinical implications for immunotherapy
Over the past decade, the emergence of effective immunotherapies has revolutionized the
clinical management of many types of cancers. However, long-term durable tumour control …
clinical management of many types of cancers. However, long-term durable tumour control …
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
CD8+ T cell–dependent killing of cancer cells requires efficient presentation of tumor
antigens by human leukocyte antigen class I (HLA-I) molecules. However, the extent to …
antigens by human leukocyte antigen class I (HLA-I) molecules. However, the extent to …
Common West African HLA antigens are associated with protection from severe malaria
A large case-control study of malaria in West African children shows that a human leucocyte
class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1* 1302–DQB1* 0501) …
class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1* 1302–DQB1* 0501) …
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
Functional diversity of the highly polymorphic human leukocyte antigen class I (HLA-I) genes
underlies successful immunologic control of both infectious disease and cancer. The …
underlies successful immunologic control of both infectious disease and cancer. The …
Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection
RA Kaslow, M Carrington, R Apple, L Park, A Munoz… - Nature medicine, 1996 - nature.com
Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune
response to foreign antigens. Molecular and serologic techniques were used to identify …
response to foreign antigens. Molecular and serologic techniques were used to identify …
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and …
RM Zinkernagel, PC Doherty - Advances in immunology, 1979 - Elsevier
Publisher Summary This chapter focuses on the important discovery that virus-specific
cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by …
cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by …
The Influence of HLA Genotype on AIDS
M Carrington, SJ O'Brien - Annual review of medicine, 2003 - annualreviews.org
Genetic resistance to infectious diseases is likely to involve a complex array of immune-
response and other genes with variants that impose subtle but significant consequences on …
response and other genes with variants that impose subtle but significant consequences on …
The nature of selection on the major histocompatibility complex
V Apanius, D Penn, PR Slev, LR Ruff… - Critical Reviews™ in …, 2017 - dl.begellhouse.com
Only natural selection can account for the extreme genetic diversity of genes of the major
histocompatibility complex (MHC). Although the structure and function of classic MHC genes …
histocompatibility complex (MHC). Although the structure and function of classic MHC genes …
Genetic factors and the intestinal microbiome guide development of microbe-based therapies for inflammatory bowel diseases
The intestinal microbiota is a dynamic community of bacteria, fungi, and viruses that
mediates mucosal homeostasis and physiology. Imbalances in the microbiome and aberrant …
mediates mucosal homeostasis and physiology. Imbalances in the microbiome and aberrant …