The TNF family of ligands and receptors: communication modules in the immune system and beyond

C Dostert, M Grusdat, E Letellier… - Physiological …, 2019 - journals.physiology.org
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues

S Yu, F Luo, Y Xu, Y Zhang, LH ** - Frontiers in Immunology, 2022 - frontiersin.org
The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

Drosophila melanogaster: A Model Organism to Study Cancer

Z Mirzoyan, M Sollazzo, M Allocca, AM Valenza… - Frontiers in …, 2019 - frontiersin.org
Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

Microenvironmental autophagy promotes tumour growth

NS Katheder, R Khezri, F O'Farrell, SW Schultz, A Jain… - Nature, 2017 - nature.com
As malignant tumours develop, they interact intimately with their microenvironment and can
activate autophagy, a catabolic process which provides nutrients during starvation. How …

Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut

A Petsakou, Y Liu, Y Liu, A Comjean, Y Hu, N Perrimon - Nature, 2023 - nature.com
A fundamental and unresolved question in regenerative biology is how tissues return to
homeostasis after injury. Answering this question is essential for understanding the …

Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model

JE La Marca, HE Richardson - Frontiers in cell and developmental …, 2020 - frontiersin.org
The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many
functions, regulating a diversity of processes: from cell movement during embryogenesis to …

Inter-cell type interactions that control JNK signaling in the Drosophila intestine

P Zhang, SM Pronovost, M Marchetti, C Zhang… - Nature …, 2024 - nature.com
JNK signaling is a critical regulator of inflammation and regeneration, but how it is controlled
in specific tissue contexts remains unclear. Here we show that, in the Drosophila intestine …

Design strategy and recent progress of fluorescent probe for noble metal ions (Ag, Au, Pd, and Pt)

M She, Z Wang, J Chen, Q Li, P Liu, F Chen… - Coordination Chemistry …, 2021 - Elsevier
Abstract Noble metals including Ag, Au, Pd, and Pt were widely applied in various aspects of
human social life, industrial manufacture, healthcare, and scientific research. The ion form of …

The Drosophila TNF Eiger is an adipokine that acts on insulin-producing cells to mediate nutrient response

N Agrawal, R Delanoue, A Mauri, D Basco, M Pasco… - Cell metabolism, 2016 - cell.com
Adaptation of organisms to ever-changing nutritional environments relies on sensor tissues
and systemic signals. Identification of these signals would help understand the physiological …

Extracellular reactive oxygen species drive apoptosis-induced proliferation via Drosophila macrophages

CE Fogarty, N Diwanji, JL Lindblad, M Tare… - Current Biology, 2016 - cell.com
Apoptosis-induced proliferation (AiP) is a compensatory mechanism to maintain tissue size
and morphology following unexpected cell loss during normal development, and may also …