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Ebola virus disease
Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
A detailed overview of immune escape, antibody escape, partial vaccine escape of SARS-CoV-2 and their emerging variants with escape mutations
The infective SARS-CoV-2 is more prone to immune escape. Presently, the significant
variants of SARS-CoV-2 are emerging in due course of time with substantial mutations …
variants of SARS-CoV-2 are emerging in due course of time with substantial mutations …
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes
Coronaviruses are adept at evading host antiviral pathways induced by viral double-
stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease …
stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease …
The pathogenesis of Ebola virus disease
L Baseler, DS Chertow, KM Johnson… - Annual Review of …, 2017 - annualreviews.org
For almost 50 years, ebolaviruses and related filoviruses have been repeatedly reemerging
across the vast equatorial belt of the African continent to cause epidemics of highly fatal …
across the vast equatorial belt of the African continent to cause epidemics of highly fatal …
[HTML][HTML] RIG-I in RNA virus recognition
Antiviral immunity is initiated upon host recognition of viral products via non-self molecular
patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition …
patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition …
Pathogenicity and virulence of Marburg virus
Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks
occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever …
occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever …
[HTML][HTML] Ebola haemorrhagic fever
H Feldmann, TW Geisbert - The Lancet, 2011 - thelancet.com
Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man,
designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The …
designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The …
African swine fever virus E120R protein inhibits interferon beta production by interacting with IRF3 to block its activation
African swine fever is a devastating disease of swine caused by African swine fever virus
(ASFV). The pathogenesis of the disease remains largely unknown, leaving the spread of …
(ASFV). The pathogenesis of the disease remains largely unknown, leaving the spread of …
Actin cytoskeleton remodeling primes RIG-I-like receptor activation
The current dogma of RNA-mediated innate immunity is that sensing of immunostimulatory
RNA ligands is sufficient for the activation of intracellular sensors and induction of interferon …
RNA ligands is sufficient for the activation of intracellular sensors and induction of interferon …
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses
The 2′, 5′-oligoadenylate (2-5A) synthetase (OAS)–RNase L system is an IFN-induced
antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS. Although all three …
antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS. Although all three …