Natural glycosaminoglycans (GAGs) are arguably the most diverse collection of natural
products. Unfortunately, this bounty of structures remains untapped. Decades of research …

Importance Direct oral anticoagulant (DOAC)–associated intracranial hemorrhage (ICH) has
high morbidity and mortality. The safety and outcome data of DOAC reversal agents in ICH …

Direct oral anticoagulants (DOACs) are recommended for the prevention of
thromboembolism in patients with atrial fibrillation (AF), and are now preferred over vitamin …

Now in its sixth edition, Robert M. Bojar's Manual of Perioperative Care in Adult Cardiac
Surgery remains the go-to practical guide for all of those involved in the care of the cardiac …

Purpose The aim of this study was to develop a novel apixaban-loaded solid self-
emulsifying drug delivery system (S-SEDDS) to enhance oral bioavailability. Methods Oils …

The factors that predispose an individual to a higher risk of death from COVID-19 are poorly
understood. The goal of the study was to identify factors associated with risk of death among …

Aim The objective of this study was to enhance the aqueous solubility and oral
bioavailability of nearly water-insoluble apixaban (APX) using polymeric nano-aggregates …

Objectives Rivaroxaban (RXB), a novel Xa inhibitor having groundbreaking therapeutic
potential. However, this drug is associated with few limitations, including its …

Apixaban and rivaroxaban are the two most prescribed direct factor Xa inhibitors. With the
increased use of DOACs in real-world settings, safety and efficacy concerns have emerged …

This document is an update of the multidisciplinary document HEMOMAS, published in 2016
with the endorsement of the Spanish Scientific Societies of Anaesthesiology (SEDAR) …