Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

The interactions between cancer cells and their micro-and macroenvironment create a
context that promotes tumour growth and protects it from immune attack. The functional …

Sáez, Juan C., Viviana M. Berthoud, María C. Brañes, Agustín D. Martínez, and Eric C.
Beyer. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions …

В монографии проанализированы основные концепции о природе старения, история
их возникновения и эволюция. Изложены современные представления о …

Phorbol esters (eg, TPA) activate protein kinase C (PKC), increase connexin43 (Cx43)
phosphorylation, and decrease cell–cell communication via gap junctions in many cell …

Establishment of shape during embryonic development, and the maintenance of shape
against injury or tumorigenesis, requires constant coordination of cell behaviors toward the …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Connexins constitute a large family of trans-membrane proteins that allow intercellular
communication and the transfer of ions and small signaling molecules between cells …

Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …