Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury

NR Strogulski, LV Portela, BM Polster… - Journal of …, 2023 - Wiley Online Library
Traumatic brain injury (TBI) is a devastating neurological disorder caused by a physical
impact to the brain that promotes diffuse damage and chronic neurodegeneration. Key …

[HTML][HTML] A tutorial on optical photothermal infrared (O-PTIR) microscopy

CB Prater, M Kansiz, JX Cheng - APL photonics, 2024 - pubs.aip.org
This tutorial reviews the rapidly growing field of optical photothermal infrared (O-PTIR)
spectroscopy and chemical imaging. O-PTIR is an infrared super-resolution measurement …

Single-cell map** of lipid metabolites using an infrared probe in human-derived model systems

Y Bai, CM Camargo, SMK Glasauer, R Gifford… - Nature …, 2024 - nature.com
Understanding metabolic heterogeneity is the key to uncovering the underlying mechanisms
of metabolic-related diseases. Current metabolic imaging studies suffer from limitations …

Label-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos

N Gvazava, SC Konings, E Cepeda-Prado… - Journal of the …, 2023 - ACS Publications
Label-free chemical imaging of living and functioning systems is the holy grail of
biochemical research. However, existing techniques often require extensive sample …

Monitoring Phenotype Heterogeneity at the Single-Cell Level within Bacillus Populations Producing Poly-3-hydroxybutyrate by Label-Free Super-resolution Infrared …

C Lima, H Muhamadali, R Goodacre - Analytical Chemistry, 2023 - ACS Publications
Phenotypic heterogeneity is commonly found among bacterial cells within microbial
populations due to intrinsic factors as well as equip** the organisms to respond to …

Structural Map** of Protein Aggregates in Live Cells Modeling Huntington's Disease

Z Guo, G Chiesa, J Yin, A Sanford, S Meier… - Angewandte …, 2024 - Wiley Online Library
While protein aggregation is a hallmark of many neurodegenerative diseases, acquiring
structural information on protein aggregates inside live cells remains challenging …

[HTML][HTML] 3D micro-CT and O-PTIR spectroscopy bring new understanding of the influence of filler content in dental resin composites

HJ Haugen, Q Ma, S Linskens, M Par, VN Mandic… - Dental materials, 2024 - Elsevier
Background Dental resin composites' performance is intricately linked to their polymerisation
shrinkage characteristics. This study compares polymerisation shrinkage using advanced …

Precision proteoform design for 4R tau isoform selective templated aggregation

AP Longhini, A DuBose, S Lobo… - Proceedings of the …, 2024 - National Acad Sciences
Prion-like spread of disease-specific tau conformers is a hallmark of all tauopathies. A 19-
residue probe peptide containing a P301L mutation and spanning the R2/R3 splice junction …

Mid-infrared Photothermal Imaging: Instrument and Life Science Applications

X Teng, M Li, H He, D Jia, J Yin, R Bolarinho… - Analytical …, 2024 - ACS Publications
Understanding biological processes at the molecular level is crucial for advancements in life
science, including disease diagnosis, pharmacology, and biotechnology. Visualizing …

Spatially Resolved Near Field Spectroscopy of Vibrational Polaritons at the Small N Limit

O Hirschmann, HH Bhakta, WJM Kort-Kamp… - ACS …, 2024 - ACS Publications
Vibrational polaritons, which have been primarily studied in Fabry–Pérot cavities with a
large number of molecules (N∼ 106–1010) coupled to the resonator mode, exhibit various …