Targeting macrophages in cancer: from bench to bedside
AR Poh, M Ernst - Frontiers in oncology, 2018 - frontiersin.org
Macrophages are a major component of the tumor microenvironment and orchestrate
various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype …
various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype …
Tumor microenvironment in gastric cancers
The tumor microenvironment favors the growth and expansion of cancer cells. Many cell
types are involved in the tumor microenvironment such as inflammatory cells, fibroblasts …
types are involved in the tumor microenvironment such as inflammatory cells, fibroblasts …
Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications
DM Hardbower, M Asim, PB Luis… - Proceedings of the …, 2017 - National Acad Sciences
Macrophage activation is a critical step in host responses during bacterial infections.
Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has …
Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has …
The role of polyamines in the regulation of macrophage polarization and function
Naturally occurring polyamines are ubiquitously distributed and play important roles in cell
development, amino acid and protein synthesis, oxidative DNA damage, proliferation, and …
development, amino acid and protein synthesis, oxidative DNA damage, proliferation, and …
Alternatively activated macrophages in infection and autoimmunity
DL Fairweather, D Cihakova - Journal of autoimmunity, 2009 - Elsevier
Macrophages are innate immune cells that play an important role in activation of the immune
response and wound healing. Pathogens that require T helper-type 2 (Th2) responses for …
response and wound healing. Pathogens that require T helper-type 2 (Th2) responses for …
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and
exerts significant influence on their progression. Macrophages and neutrophils are major …
exerts significant influence on their progression. Macrophages and neutrophils are major …
Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes
The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa
during early childhood and persists throughout life. The organism has evolved multiple …
during early childhood and persists throughout life. The organism has evolved multiple …
Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis
T Yang, R Wang, H Liu, L Wang, J Li, S Wu, X Chen… - Life Sciences, 2021 - Elsevier
Aims We will investigate the anti-inflammatory activities of berberine (BBR) in treating
chronic atrophic gastritis (CAG) induced by Helicobacter pylori (H. pylori). Furthermore, the …
chronic atrophic gastritis (CAG) induced by Helicobacter pylori (H. pylori). Furthermore, the …
[HTML][HTML] BRD4 regulates glycolysis-dependent Nos2 expression in macrophages upon H pylori infection
Background & Aims Metabolic reprogramming is essential for the activation and functions of
macrophages, including bacterial killing and cytokine production. Bromodomain-containing …
macrophages, including bacterial killing and cytokine production. Bromodomain-containing …
Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors
H Oshima, K Hioki, BK Popivanova, K Oguma… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Helicobacter pylori infection induces an inflammatory response,
which can contribute to gastric tumorigenesis. Induction of cyclooxygenase-2 (COX-2) …
which can contribute to gastric tumorigenesis. Induction of cyclooxygenase-2 (COX-2) …