The epitranscriptome beyond m6A
Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …
Post-transcriptional gene regulation by mRNA modifications
The recent discovery of reversible mRNA methylation has opened a new realm of post-
transcriptional gene regulation in eukaryotes. The identification and functional …
transcriptional gene regulation in eukaryotes. The identification and functional …
Quantitative profiling of pseudouridylation dynamics in native RNAs with nanopore sequencing
Nanopore RNA sequencing shows promise as a method for discriminating and identifying
different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing …
different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing …
Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function
KE Sloan, AS Warda, S Sharma, KD Entian… - RNA biology, 2017 - Taylor & Francis
ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing
NM Martinez, A Su, MC Burns, JK Nussbacher… - Molecular cell, 2022 - cell.com
Pseudouridine is a modified nucleotide that is prevalent in human mRNAs and is
dynamically regulated. Here, we investigate when in their life cycle mRNAs become …
dynamically regulated. Here, we investigate when in their life cycle mRNAs become …
Detecting RNA modifications in the epitranscriptome: predict and validate
RNA modifications are emerging players in the field of post-transcriptional regulation of
gene expression, and are attracting a comparable degree of research interest to DNA and …
gene expression, and are attracting a comparable degree of research interest to DNA and …
Epitranscriptome sequencing technologies: decoding RNA modifications
In recent years, major breakthroughs in RNA-modification-mediated regulation of gene
expression have been made, leading to the emerging field of epitranscriptomics. Our …
expression have been made, leading to the emerging field of epitranscriptomics. Our …
Functional diversity of small nucleolar RNAs
T Bratkovič, J Božič, B Rogelj - Nucleic acids research, 2020 - academic.oup.com
Small nucleolar RNAs (snoRNAs) are short non-protein-coding RNAs with a long-
recognized role in tuning ribosomal and spliceosomal function by guiding ribose methylation …
recognized role in tuning ribosomal and spliceosomal function by guiding ribose methylation …
Detection technologies for RNA modifications
Y Zhang, L Lu, X Li - Experimental & Molecular Medicine, 2022 - nature.com
To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
Regulation of translation by site-specific ribosomal RNA methylation
MD Jansson, SJ Häfner, K Altinel, D Tehler… - Nature structural & …, 2021 - nature.com
Ribosomes are complex ribozymes that interpret genetic information by translating
messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been …
messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been …