Mechanisms of IGF-1-mediated regulation of skeletal muscle hypertrophy and atrophy
T Yoshida, P Delafontaine - Cells, 2020 - mdpi.com
Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …
The GH/IGF-1 axis in ageing and longevity
Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-
1), declines over time until only low levels can be detected in individuals aged≥ 60 years …
1), declines over time until only low levels can be detected in individuals aged≥ 60 years …
Autophagy in cardiovascular aging
Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …
promotes the structural and functional declines of both the heart and the blood circulation …
The role of liver-derived insulin-like growth factor-I
IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …
Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart
Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin
(mTOR) signaling, thereby regulating metabolism and suppressing protein synthesis …
(mTOR) signaling, thereby regulating metabolism and suppressing protein synthesis …
Human conditions of insulin-like growth factor-I (IGF-I) deficiency
JE Puche, I Castilla-Cortázar - Journal of translational medicine, 2012 - Springer
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …
Cardiac aging: from molecular mechanisms to significance in human health and disease
Cardiovascular diseases (CVDs) are the major causes of death in the western world. The
incidence of cardiovascular disease as well as the rate of cardiovascular mortality and …
incidence of cardiovascular disease as well as the rate of cardiovascular mortality and …
Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
S **e, SC Xu, W Deng, Q Tang - Signal transduction and targeted …, 2023 - nature.com
Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …
The aging heart
Aging results in progressive deteriorations in the structure and function of the heart and is a
dominant risk factor for cardiovascular diseases, the leading cause of death in Western …
dominant risk factor for cardiovascular diseases, the leading cause of death in Western …
New insights into IGF-1 signaling in the heart
Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy,
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …